Determinants of low health-related quality of life in patients with myelodysplastic syndromes: EUMDS registry study

Autor: Stojkov, I., Conrads-Frank, A., Rochau, U., Arvandi, M., Koinig, K.A., Schomaker, M., Mittelman, M., Fenaux, P., Bowen, D., Sanz, G.F., Malcovati, L., Langemeijer, S.M.C., Germing, U., Madry, K., Guerci-Bresler, A., Culligan, D.J., Kotsianidis, I., Sanhes, L., Mills, J., Puntscher, S., Schmid, D., Marrewijk, C.J. van, Smith, A, Efficace, F., Witte, T.J. de, Stauder, R., Siebert, U.
Rok vydání: 2022
Předmět:
Zdroj: Blood Advances, 7, 2772-2783
Blood Advances, 7, 12, pp. 2772-2783
ISSN: 2473-9537
2772-2783
2473-9529
Popis: Item does not contain fulltext Patients with myelodysplastic syndromes (MDS) frequently experience a significant symptom burden, which reduces health-related quality of life (HRQoL). We aimed to identify determinants of low HRQoL in patients recently diagnosed with MDS, for guiding early intervention strategies. We evaluated longitudinal data in 2205 patients with MDS during their first year after diagnosis. Median values of EQ-5D 3-level (EQ-5D-3L) index (0.78) and visual analog scale (VAS) score (0.70) were used as thresholds for low HRQoL. In addition, the 5 dimensions of EQ-5D-3L were analyzed for impairments (any level vs "no problem" category). After multiple imputation of missing values, we used generalized estimating equations (GEE) to estimate odds ratios (OR) for univariable determinant screening (P < .15), and to subsequently derive multivariable models for low HRQoL with 95% confidence intervals (CI). Multivariable GEE analysis showed the following independent determinants (OR, 95% CI) for low EQ-5D index: increased age (60-75 years: 1.33, 1.01-1.75; >75: 1.84, 1.39-2.45), female sex (1.70, 1.43-2.03), high serum ferritin level (≥1000 vs ≤300 μg/L: 1.41, 1.06-1.87), comorbidity burden (per unit: 1.11, 1.02-1.20), and reduced Karnofsky performance status (KPS, per 10 units: 0.62, 0.58-0.67). For low VAS score, additional determinants were transfusion dependence (1.53, 1.03-2.29), low hemoglobin
Databáze: OpenAIRE
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