| Autor: |
Galinier M, Jm, Senard, Srour A, Ligou V, Philippe Valet, Glock Y, Massabuau P, Roux D, Jl, Montastruc, Jp, Bounhoure |
| Jazyk: |
francouzština |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Europe PubMed Central |
| ISSN: |
0003-9683 |
| Popis: |
While most prior studies examined late stages of heart failure, we determined initial changes of beta-adrenergic receptors (beta-AR) during left ventricular chronic volume and pressure overload. We investigated right auricular (RA) and left ventricular (LV) beta-AR density (Bmax, fmoles/mg protein) and beta 1-AR percentage in two groups of patients undergoing valve replacement without LV systolic dysfunction (LV ejection fractionor = 60%), with normal plasma catecholamine levels and echocardiography LV hypertrophy. These results were compared with the values of a control group, composed by 8 patients with mitral stenosis and 5 cardiac transplant donors, and the values of 5 patients undergoing heart transplantation because of end-stage idiopathic dilated cardiomyopathy. These results show that, before alteration of LV systolic function occurs, left ventricular chronic overload induces a selective down-regulation of LV beta 1-AR compensated by an increase in beta 2-AR. These variations may be due to LV hypertrophy induced by volume or pressure overload. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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