| Autor: |
Hillaire D, Jean Claude Chomel, Lesure F, Renouil M, Musenger C, Pierson F, Berthelon M, Lenoir G, Gérard G, Bois E |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Europe PubMed Central |
| ISSN: |
0003-3995 |
| Popis: |
The frequencies of the delta F 508 mutation and haplotypes linked to the cystic fibrosis (CF) gene and detected with DNA probes XV-2C and KM-19 have been studied in the population of Reunion Island, a French province located in the Indian Ocean. The deletion was present in 41.3% of CF chromosomes, whereas this proportion is about 70% in the French population. The delta F 508 mutation was associated with the haplotype B defined by the DNA markers XV-2C (allele 1) and KM-19 (allele 2) in 76.4% of CF chromosomes, while this proportion is over 90% in the French population. Founder effect, genetic drift and admixture can explain these differences. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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