Leptin-based immune intervention: Current status and future directions

Autor:	Antonio La Cava, Matarese, G., Ebling, F. M., Hahn, B. H.
Přispěvatelé:	La Cava, A, Matarese, Giuseppe, Ebling, Fm, Hahn, Bh
Předmět:	Inflammation Leptin T-Lymphocytes Animals Humans Nutritional Status Receptors Leptin Receptors Cell Surface Autoimmune Diseases Signal Transduction
Zdroj:	Scopus-Elsevier 82 (2003): 4–11. info:cnr-pdr/source/autori:La Cava A, Matarese G, Ebling FM, and Hahn BH./titolo:Leptin-based immune intervention: current status and future directions./doi:/rivista:/anno:2003/pagina_da:4/pagina_a:11/intervallo_pagine:4–11/volume:82
Popis:	Current understanding of the role of leptin has expanded from its narrow association with obesity to a variety of effects on different biological processes including immune function. More specifically, leptin links nutritional status and energy balance to regulation of pro-inflammatory T-helper 1 immune responses. This has prompted several studies of targeted intervention with leptin antagonists in rodents to suppress onset and/or progression of chronic inflammation and autoimmunity. This review presents current preclinical evidence and potential applications for leptin-based immune approaches aimed at improving therapy for chronic and autoimmune conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bd512a851a98e658efbe2091222e0a65 http://www.scopus.com/inward/record.url?eid=2-s2.0-0345832390&partnerID=MN8TOARS Zobrazit plný text záznamu