Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer
| Autor: | Yang, L, Roberts, D, Takhar, M, Erho, N, Bibby, B, Thiruthaneeswaran, N, Bhandari, V, Cheng, W, Haider, S, McCorry, A, McArt, D, Jain, S, Alshalalfa, M, Ross, A, Schaffer, E, Den, R, Jeffrey Karnes, R, Klein, E, Hoskin, P, Freedland, S, Lamb, A, Neal, D, Buffa, F, Bristow, R, Boutros, P, Davicioni, E, Choudhury, A, West, C |
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| Rok vydání: | 2018 |
| Předmět: |
Urologic Diseases
Male Aging Prognostic biomarker Clinical Sciences lcsh:Medicine Gene expression signature Disease-Free Survival SDG 3 - Good Health and Well-being Clinical Research Genetics Humans Neoplasm Metastasis Hypoxia Cancer lcsh:R5-920 screening and diagnosis Neoplastic Prostate cancer Manchester Cancer Research Centre Radiotherapy ResearchInstitutes_Networks_Beacons/mcrc lcsh:R Prostatic Neoplasms 4.1 Discovery and preclinical testing of markers and technologies Gene Expression Regulation Neoplastic Survival Rate Detection Gene Expression Regulation Public Health and Health Services Tumor Hypoxia Patient Safety lcsh:Medicine (General) |
| Zdroj: | EBioMedicine, Vol 31, Iss, Pp 182-189 (2018) Yang, L, Roberts, D, Takhar, M, Erho, N, Bibby, B A S, Thiruthaneeswaran, N, Bhandari, V, Cheng, W-C, Haider, S, McCorry, A M B, McArt, D, Jain, S, Alshalalfa, M, Ross, A, Schaffer, E, Den, R B, Jeffrey Karnes, R, Klein, E, Hoskin, P J, Freedland, S J, Lamb, A D, Neal, D E, Buffa, F M, Bristow, R G, Boutros, P C, Davicioni, E, Choudhury, A & West, C M L 2018, ' Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer ', EBioMedicine, vol. 31, pp. 182-189 . https://doi.org/10.1016/j.ebiom.2018.04.019 Yang, L, Roberts, D, Takhar, M, Erho, N, Bibby, B A S, Thiruthaneeswaran, N, Bhandari, V, Cheng, W-C, Haider, S, McCorry, A M B, McArt, D, Jain, S, Alshalalfa, M, Ross, A, Schaffer, E, Den, R B, Jeffrey Karnes, R, Klein, E, Hoskin, P J, Freedland, S J, Lamb, A D, Neal, D E, Buffa, F M, Bristow, R G, Boutros, P C, Davicioni, E, Choudhury, A & West, C M L 2018, ' Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer. ', EBioMedicine, vol. 31, pp. 182-189 . https://doi.org/10.1016/j.ebiom.2018.04.019 |
| ISSN: | 2352-3964 |
| Popis: | Background: Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate a hypoxia-related mRNA signature for localized prostate cancer. Method: Hypoxia genes were identified in vitro via RNA-sequencing and combined with in vivo gene co-expression analysis to generate a signature. The signature was independently validated in eleven prostate cancer cohorts and a bladder cancer phase III randomized trial of radiotherapy alone or with carbogen and nicotinamide (CON). Results: A 28-gene signature was derived. Patients with high signature scores had poorer biochemical recurrence free survivals in six of eight independent cohorts of prostatectomy-treated patients (Log rank test P |
| Databáze: | OpenAIRE |
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