Lung function and self-rated symptoms in healthy volunteers after exposure to hydrotreated vegetable oil (HVO) exhaust with and without particles
| Autor: | Gren, Louise, Dierschke, Katrin, Mattsson, Fredrik, Assarsson, Eva, Krais, Annette M., Kåredal, Monica, Lovén, Karin, Löndahl, Jakob, Pagels, Joakim, Strandberg, Bo, Tunér, Martin, Xu, Yiyi, Wollmer, Per, Albin, Maria, Nielsen, Jörn, Gudmundsson, Anders, Wierzbicka, Aneta |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Pulmonary function
Forced oscillation technique (FOT) Research Peak expiratory flow (PEF) respiratory system HD7260-7780.8 Renewable diesel complex mixtures Healthy Volunteers Inhalation Peak nasal inspiratory flow (PNIF) RA1190-1270 Occupational exposure limits (OELs) Toxicology. Poisons Symptoms Humans Plant Oils Industrial hygiene. Industrial welfare Non-road vehicles Particulate Matter Aerosol Lung Vehicle Emissions |
| Zdroj: | Particle and Fibre Toxicology Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-20 (2022) |
| ISSN: | 1743-8977 |
| Popis: | Background Diesel engine exhaust causes adverse health effects. Meanwhile, the impact of renewable diesel exhaust, such as hydrotreated vegetable oil (HVO), on human health is less known. Nineteen healthy volunteers were exposed to HVO exhaust for 3 h in a chamber with a double-blind, randomized setup. Exposure scenarios comprised of HVO exhaust from two modern non-road vehicles with 1) no aftertreatment system (‘HVOPM+NOx’ PM1: 93 µg m−3, EC: 54 µg m−3, NO: 3.4 ppm, NO2: 0.6 ppm), 2) an aftertreatment system containing a diesel oxidation catalyst and a diesel particulate filter (‘HVONOx’ PM1: ~ 1 µg m−3, NO: 2.0 ppm, NO2: 0.7 ppm) and 3) filtered air (FA) as control. The exposure concentrations were in line with current EU occupational exposure limits (OELs) of NO, NO2, formaldehyde, polycyclic aromatic hydrocarbons (PAHs), and the future OEL (2023) of elemental carbon (EC). The effect on nasal patency, pulmonary function, and self-rated symptoms were assessed. Calculated predicted lung deposition of HVO exhaust particles was compared to data from an earlier diesel exhaust study. Results The average total respiratory tract deposition of PM1 during HVOPM+NOx was 27 µg h−1. The estimated deposition fraction of HVO PM1 was 40–50% higher compared to diesel exhaust PM1 from an older vehicle (earlier study), due to smaller particle sizes of the HVOPM+NOx exhaust. Compared to FA, exposure to HVOPM+NOx and HVONOx caused higher incidence of self-reported symptoms (78%, 63%, respectively, vs. 28% for FA, p |
| Databáze: | OpenAIRE |
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