Eggs early in complementary feeding increase choline pathway biomarkers and DHA: a randomized controlled trial in Ecuador
Autor: | Iannotti, LL, Lutter, CK, Waters, WF, Riofrío, CAG, Malo, C, Reinhart, G, Palacios, A, Karp, C, Chapnick, M, Cox, K, Aguirre, S, Narvaez, L, López, F, Sidhu, R, Kell, P, Jiang, X, Fujiwara, H, Ory, DS, Young, R, Stewart, CP |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Rural Population
Male Docosahexaenoic Acids Eggs Clinical Trials and Supportive Activities Nutritional Status Methylation Medical and Health Sciences Choline Methylamines Methionine Engineering egg nutrition Population Groups children Clinical Research choline Humans betaine Infant Nutritional Physiological Phenomena Growth Disorders Nutrition vitamin B-12 Pediatric Nutrition & Dietetics Prevention International Nutrition Correction Infant Vitamin B 12 Deficiency Feeding Behavior docosahexaenoic acid Body Height Diet Vitamin B 12 Female Ecuador Dimethylamines Biomarkers |
Zdroj: | The American Journal of Clinical Nutrition The American journal of clinical nutrition, vol 106, iss 6 Am J Clin Nutr Iannotti, LL; Lutter, CK; Waters, WF; Riofrío, CAG; Malo, C; Reinhart, G; et al.(2017). Eggs early in complementary feeding increase choline pathway biomarkers and DHA: A randomized controlled trial in Ecuador. American Journal of Clinical Nutrition, 106(6), 1482-1489. doi: 10.3945/ajcn.117.160515. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/8xr9j9n5 |
ISSN: | 1938-3207 0002-9165 |
Popis: | Background: Choline status has been associated with stunting among young children. Findings from this study showed that an egg intervention improved linear growth by a length-for-age z score of 0.63. Objective: We aimed to test the efficacy of eggs introduced early in complementary feeding on plasma concentrations of biomarkers in choline pathways, vitamins B-12 and A, and essential fatty acids. Design: A randomized controlled trial, the Lulun (“egg” in Kichwa) Project, was conducted in a rural indigenous population of Ecuador. Infants aged 6–9 mo were randomly assigned to treatment (1 egg/d for 6 mo; n = 80) and control (no intervention; n = 83) groups. Socioeconomic data, anthropometric measures, and blood samples were collected at baseline and endline. Household visits were made weekly for morbidity surveillance. We tested vitamin B-12 plasma concentrations by using chemiluminescent competitive immunoassay and plasma concentrations of choline, betaine, dimethylglycine, retinol, essential fatty acids, methionine, dimethylamine (DMA), trimethylamine, and trimethylamine-N-oxide (TMAO) with the use of liquid chromatography–tandem mass spectrometry. Results: Socioeconomic factors and biomarker concentrations were comparable at baseline. Of infants, 11.4% were vitamin B-12 deficient and 31.7% marginally deficient at baseline. In adjusted generalized linear regression modeling, the egg intervention increased plasma concentrations compared with control by the following effect sizes: choline, 0.35 (95% CI: 0.12, 0.57); betaine, 0.29 (95% CI: 0.01, 0.58); methionine, 0.31 (95% CI: 0.03, 0.60); docosahexaenoic acid, 0.43 (95% CI: 0.13, 0.73); DMA, 0.37 (95% CI: 0.37, 0.69); and TMAO, 0.33 (95% CI: 0.08, 0.58). No significant group differences were found for vitamin B-12, retinol, linoleic acid (LA), a-linolenic acid (ALA), or ratios of betaine to choline and LA to ALA. Conclusion: The findings supported our hypothesis that early introduction of eggs significantly improved choline and other markers in its methyl group metabolism pathway. This trial was registered at clinicaltrials.gov as NCT02446873. |
Databáze: | OpenAIRE |
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