| Autor: |
Luca Tamagnone, Partanen, J., Armstrong, E., Lasota, J., Ohgami, K., Tazunoki, T., Laforgia, S., Huebner, K., Alitalo, K. |
| Jazyk: |
angličtina |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Scopus-Elsevier |
| Popis: |
The human ryk tyrosine kinase cDNA was originally identified as a PCR-amplified cDNA fragment (JTK5) from K562 leukemia cells and found to represent a ubiquitously expressed gene (Partanen et al., 1990). The open reading frame of human ryk, reported here, encodes a novel type of putative tyrosine kinase of 607 amino acid residues, having two potential transmembrane domains and homology to receptor tyrosine kinases, such as met (HGF/SF-R) and IGF-1R, in its catalytic domain. The gene maps to human chromosome 3q11-25. Expression of the 3.4 kb ryk mRNA was found in all human adult tissues examined. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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