Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry
| Autor: | Juan, Thomas, Géminard, Charles, Coutelis, Jean-Baptiste, Cérézo, Delphine, Polès, Sophie, Noselli, Stéphane, Fürthauer, Maximilian |
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| Přispěvatelé: | Herrada, Anthony, Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015) |
| Rok vydání: | 2017 |
| Předmět: |
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
Embryo Nonmammalian [SDV]Life Sciences [q-bio] Science Left-Right Determination Factors Cell Polarity Gene Expression Regulation Developmental [SDV.CAN]Life Sciences [q-bio]/Cancer Myosins Zebrafish Proteins Article Animals Genetically Modified [SDV.CAN] Life Sciences [q-bio]/Cancer Mutation Animals lcsh:Q Cilia lcsh:Science ComputingMilieux_MISCELLANEOUS [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology Zebrafish Body Patterning |
| Zdroj: | Nature Communications Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018) Nature Communications, 2018, 9 (1), pp.1942. ⟨10.1038/s41467-018-04284-8⟩ Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-04284-8⟩ Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.1942. ⟨10.1038/s41467-018-04284-8⟩ |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-04284-8⟩ |
| Popis: | The establishment of left–right (LR) asymmetry is fundamental to animal development, but the identification of a unifying mechanism establishing laterality across different phyla has remained elusive. A cilia-driven, directional fluid flow is important for symmetry breaking in numerous vertebrates, including zebrafish. Alternatively, LR asymmetry can be established independently of cilia, notably through the intrinsic chirality of the acto-myosin cytoskeleton. Here, we show that Myosin1D (Myo1D), a previously identified regulator of Drosophila LR asymmetry, is essential for the formation and function of the zebrafish LR organizer (LRO), Kupffer’s vesicle (KV). Myo1D controls the orientation of LRO cilia and interacts functionally with the planar cell polarity (PCP) pathway component VanGogh-like2 (Vangl2), to shape a productive LRO flow. Our findings identify Myo1D as an evolutionarily conserved regulator of animal LR asymmetry, and show that functional interactions between Myo1D and PCP are central to the establishment of animal LR asymmetry. Left-right (LR) axis specification is essential for embryonic patterning but a unifying mechanism across organisms has not been identified. Here, the authors show that Myosin1D, known to regulate Drosophila LR asymmetry, controls zebrafish LR Organizer function, and is therefore a conserved regulator of animal laterality. |
| Databáze: | OpenAIRE |
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