Longevity strategies in response to light in the reef coral Stylophora pistillata
Autor: | Ottaviani, Alexandre, Eid, Rita, Zoccola, Didier, Pousse, Mélanie, Dubal, Jean-Marc, Barajas, Edwige, Jamet, Karine, Lebrigand, Kevin, Lapébie, Pascal, Baudoin, Christian, Giraud-Panis, M.J., Rouan, Alice, Beauchef, Gallic, Guéré, Christelle, Vié, Katell, Barbry, Pascal, Tambutté, Sylvie, Gilson, Eric, Allemand, Denis |
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Přispěvatelé: | Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre Scientifique de Monaco, Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Giraud-Panis, Marie-Josèphe |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Marine biology
Cell biology Light [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Coral Reefs Longevity fungi lcsh:R lcsh:Medicine Forkhead Transcription Factors Anthozoa Senescence Article [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology [SDV.BA.ZI] Life Sciences [q-bio]/Animal biology/Invertebrate Zoology [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Animals Circadian rhythms lcsh:Q Photosynthesis lcsh:Science |
Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports Scientific Reports, Nature Publishing Group, 2020, 10, pp.19937. ⟨10.1038/s41598-020-76925-2⟩ Scientific Reports, 2020, 10, pp.19937. ⟨10.1038/s41598-020-76925-2⟩ |
ISSN: | 2045-2322 |
DOI: | 10.1038/s41598-020-76925-2 |
Popis: | International audience; Aging is a multifactorial process that results in progressive loss of regenerative capacity and tissue function while simultaneously favoring the development of a large array of age-related diseases. Evidence suggests that the accumulation of senescent cells in tissue promotes both normal and pathological aging. Oxic stress is a key driver of cellular senescence. Because symbiotic long-lived reef corals experience daily hyperoxic and hypoxic transitions, we hypothesized that these long-lived animals have developed specific longevity strategies in response to light. We analyzed transcriptome variation in the reef coral Stylophora pistillata during the day–night cycle and revealed a signature of the FoxO longevity pathway. We confirmed this pathway by immunofluorescence using antibodies against coral FoxO to demonstrate its nuclear translocation. Through qPCR analysis of nycthemeral variations of candidate genes under different light regimens, we found that, among genes that were specifically up- or downregulated upon exposure to light, human orthologs of two “light-up” genes (HEY1 and LONF3) exhibited anti-senescence properties in primary human fibroblasts. Therefore, these genes are interesting candidates for counteracting skin aging. We propose a large screen for other light-up genes and an investigation of the biological response of reef corals to light (e.g., metabolic switching) to elucidate these processes and identify effective interventions for promoting healthy aging in humans. |
Databáze: | OpenAIRE |
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