Protective effect of lycopene on oral mucositis and antioxidant capacity of blood plasma in the rat exposed to gamma radiation
| Autor: | Motallebnejad, Mina, Zahedpasha, Shaghayegh, Moghadamnia, Ali Akbar, Kazemi, Sohrab, Moslemi, Daryoush, Pouramir, Mahdi, Asgharpour, Fariba |
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| Jazyk: | perština |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Caspian Journal of Internal Medicine, Vol 11, Iss 4, Pp 419-425 (2020) Caspian Journal of Internal Medicine |
| Popis: | Background: Nowadays, radiotherapy is used effectively for treatment of head and neck cancers. Mucositis is one of the most important side effects of radiotherapy. Radio-protective agents protect tissues and cells against the adverse effects due to ionizing radiation and cleave radiation-induced free radicals. Lycopene as a potent antioxidant protects cells against oxidative damage by free radical–scavenging. The present study investigated the antioxidant effect of lycopene on oral mucosa of irradiated rats. Methods: In this experimental animal study, 28 rats were placed in four groups as follows: treated with 50 mg /kg of lycopene (L50), solvent+irradiation (SR), 25 mg / kg of lycopene+irradiation (LR25), and 50 mg / kg of lycopene+irradiation (LR50). The rats received lycopene intraperitoneally. On the irradiation day (day 0) and tenth day of radiation, blood samples were taken from the animals for FRAP and TBARS tests. Results: The results showed that the LR50 group didn’t show mucositis higher than Grade 2. There was a significant difference (p |
| Databáze: | OpenAIRE |
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