Responders to Wide-Pulse, High-Frequency Neuromuscular Electrical Stimulation Show Reduced Metabolic Demand: A 31P-MRS Study in Humans
| Autor: | Wegrzyk J, Alexandre Fouré, Le Fur Y, Na, Maffiuletti, Vilmen C, Guye M, Jp, Mattei, Place N, Bendahan D, Gondin J |
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| Přispěvatelé: | Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Neuromuscular Research Laboratory [Schulthess Clinic], Schulthess Clinic, Rhumatologie [Sainte- Marguerite - APHM] ( Hôpitaux Sud), Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Institut des Sciences du Mouvement et de la Médecine du Sport, Université de Genève = University of Geneva (UNIGE), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Université de Genève (UNIGE) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Soleus muscles Phosphocreatine lcsh:R lcsh:Medicine [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] Magnetic Resonance Imaging Axons Gastrocnemius muscles Electric Stimulation Young Adult Muscle contraction Isometric Contraction Functional electrical stimulation Muscle Fatigue [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Humans lcsh:Q Female Engines Triceps lcsh:Science Fatigue Research Article |
| Zdroj: | PLoS One, vol. 10, no. 11, pp. e0143972 PLoS ONE PLoS ONE, 2015, 10 (11), pp.e0143972. ⟨10.1371/journal.pone.0143972⟩ PLoS ONE, Public Library of Science, 2015, 10 (11), pp.e0143972. ⟨10.1371/journal.pone.0143972⟩ PLoS ONE, Vol 10, Iss 11, p e0143972 (2015) Europe PubMed Central |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0143972⟩ |
| Popis: | International audience; Conventional (CONV) neuromuscular electrical stimulation (NMES) (i.e., short pulse duration, low frequencies) induces a higher energetic response as compared to voluntary contractions (VOL). In contrast, wide-pulse, high-frequency (WPHF) NMES might elicit-at least in some subjects (i.e., responders)-a different motor unit recruitment compared to CONV that resembles the physiological muscle activation pattern of VOL. We therefore hypothesized that for these responder subjects, the metabolic demand of WPHF would be lower than CONV and comparable to VOL. 18 healthy subjects performed isometric plantar flexions at 10% of their maximal voluntary contraction force for CONV (25 Hz, 0.05 ms), WPHF (100 Hz, 1 ms) and VOL protocols. For each protocol, force time integral (FTI) was quantified and subjects were classified as responders and non-responders to WPHF based on k-means clustering analysis. Furthermore, a fatigue index based on FTI loss at the end of each protocol compared with the beginning of the protocol was calculated. Phosphocreatine depletion (ΔPCr) was assessed using 31P magnetic resonance spectroscopy. Responders developed four times higher FTI's during WPHF (99 ± 37 ×103 N.s) than non-responders (26 ± 12 ×103 N.s). For both responders and non-responders, CONV was metabolically more demanding than VOL when ΔPCr was expressed relative to the FTI. Only for the responder group, the ∆PCr/FTI ratio of WPHF (0.74 ± 0.19 M/N.s) was significantly lower compared to CONV (1.48 ± 0.46 M/N.s) but similar to VOL (0.65 ± 0.21 M/N.s). Moreover, the fatigue index was not different between WPHF (-16%) and CONV (-25%) for the responders. WPHF could therefore be considered as the less demanding NMES modality-at least in this subgroup of subjects-by possibly exhibiting a muscle activation pattern similar to VOL contractions. |
| Databáze: | OpenAIRE |
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