Inflammation interferes with the assessment of vitamin A status in magnesium deficiency
| Autor: | Rayssiguier Y, Marie-Cécile Alexandre-Gouabau, Lyan B, Gueux E, Mazur A, Rock E |
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| Přispěvatelé: | Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, ProdInra, Migration |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Inflammation
Male Reference Standards RETINOL Rats [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition Random Allocation PHASE AIGUË Liver RBP [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie VITAMIN A Animals Magnesium [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Rats Wistar ACUTE PHASE Magnesium Deficiency [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | Magnesium Research Magnesium Research, John Libbey Eurotext, 2008, 21 (4), pp.237-239 Publons Magnesium Research, 2008, 21 (4), pp.237-239 Scopus-Elsevier HAL Europe PubMed Central |
| ISSN: | 0953-1424 |
| Popis: | International audience; Hyporetinemia is observed in several pathological conditions including a primary deficiency of vitamin A and has also been reported to accompany inflammatory diseases. Experimental magnesium (Mg) deficiency in rodents is accompanied by an inflammatory syndrome. The present study was designed to determine whether the acute phase response in Mg-deficient rats can modify vitamin A status. Clinical symptoms of acute phase response were observed in Mg-deficient rats and were accompanied by a reduction in plasma retinol and of plasma retinol binding protein (RBP). Mg deficiency in rats resulted in hyporetinemia without a significant decrease in liver retinol reserves. Consequently, the data strongly suggest that the decrease in plasma retinol concentration, resulting from the level of its binding protein, is related to the inflammatory effect of Mg deficiency. These results point to the possible interference of Mg deficiency on the use of plasma retinol as an indicator of vitamin A status. |
| Databáze: | OpenAIRE |
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