| Autor: |
McCoy, Jodi, Bates, Matthew, Eggett, Christopher, Siervo, Mario, Cassidy, Sophie, Newman, Jane, Moore, Sarah A., Gorman, Grainne, Trenell, Michael I., Velicki, Lazar, Seferovic, Petar M., Cleland, John G.F., MacGowan, Guy A., Turnbull, Doug M., Jakovljevic, Djordje G. |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Open Heart |
| ISSN: |
2053-3624 |
| Popis: |
Objective: Exercise intolerance is a clinical hallmark of chronic conditions. The present study determined pathophysiological mechanisms of exercise intolerance in cardiovascular, neuromuscular, and metabolic disorders.\ud \ud Methods: In a prospective cross-sectional observational study 152 patients (heart failure reduced ejection fraction, n=32; stroke, n=34; mitochondrial disease, n=28; type two diabetes, n=28; and healthy controls, n=30) performed cardiopulmonary exercise testing with metabolic and haemodynamic measurements. Peak exercise O2 consumption and cardiac power output were measures of exercise tolerance and cardiac performance.\ud \ud Results: Exercise tolerance was significantly diminished in patients compared with controls (ie, by 45% stroke, 39% mitochondria disease, and 33% diabetes and heart failure, p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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