| Autor: |
Webber, Mark A., Whitehead, Rebekah N., Mount, Manuella, Loman, Nicholas J., Pallen, Mark J., Piddock, Laura J. V. |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Journal of Antimicrobial Chemotherapy |
| ISSN: |
0305-7453 |
| Popis: |
Objectives: \ud Biocides are widely used to prevent infection. We aimed to determine whether exposure of Salmonella to various biocides could act as a driver of antibiotic resistance.\ud \ud Methods: \ud Salmonella enterica serovar Typhimurium was exposed to four biocides with differing modes of action. Antibiotic-resistant mutants were selected during exposure to all biocides and characterized phenotypically and genotypically to identify mechanisms of resistance.\ud \ud Results: \ud All biocides tested selected MDR mutants with decreased antibiotic susceptibility; these occurred randomly throughout the experiments. Mutations that resulted in de-repression of the multidrug efflux pump AcrAB-TolC were seen in MDR mutants. A novel mutation in rpoA was also selected and contributed to the MDR phenotype. Other mutants were highly resistant to both quinolone antibiotics and the biocide triclosan.\ud \ud Conclusions: \ud This study shows that exposure of bacteria to biocides can select for antibiotic-resistant mutants and this is mediated by clinically relevant mechanisms of resistance prevalent in human pathogens. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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