Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations
| Autor: | Cimino, Giuseppe, Moir, Dt, Canaani, O, Williams, K, Crist, Wm, Katzav, S, Cannizzaro, L, Lange, B, Nowell, Pc, Croce, Cm |
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| Rok vydání: | 1991 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte CD3 Complex Chromosomes Human Pair 11 Restriction Mapping Receptors Antigen T-Cell Chromosome Mapping DNA Neoplasm Precursor Cell Lymphoblastic Leukemia-Lymphoma Blotting Northern Translocation Genetic Blotting Southern Humans RNA Messenger RNA Neoplasm Chromosomes Human Pair 4 Cloning Molecular Chromosomes Human Pair 9 Chromosomes Human Pair 19 |
| Zdroj: | Cancer research. 51(24) |
| ISSN: | 0008-5472 |
| Popis: | Chromosomal region 11q23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and others. These translocations are associated with acute lymphocytic leukemia and acute myelomonocytic, monocytic, and myelogenous leukemia. From a yeast artificial chromosome containing human DNA derived from 11q23 we cloned a DNA fragment which can be used as a probe to detect rearrangements in leukemic cells from the majority of patients with the t(4;11), t(9;11), and t(11;19) translocations. The breakpoints cluster in a small DNA region of less than 5.8 kilobases. |
| Databáze: | OpenAIRE |
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