Testing a linear time invariant model for skin conductance responses by intraneural recording and stimulation
| Autor: | Gerster, Samuel, Namer, Barbara, Elam, Mikael, Bach, Dominik R |
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| Přispěvatelé: | University of Zurich, Bach, Dominik R |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
2805 Cognitive Neuroscience
Adult Male 610 Medicine & health behavioral disciplines and activities Models Biological 3206 Neuropsychology and Physiological Psychology 2806 Developmental Neuroscience Young Adult skin conductance Humans psychophysiological model Glycoproteins microneurography sympathetic nervous system Nerve Fibers Unmyelinated 3205 Experimental and Cognitive Psychology sudomotor nerve 2800 General Neuroscience Peroneal Nerve Original Articles Galvanic Skin Response Middle Aged Electric Stimulation 2807 Endocrine and Autonomic Systems Acoustic Stimulation 10054 Clinic for Psychiatry Psychotherapy and Psychosomatics 2808 Neurology Original Article Female 2803 Biological Psychiatry |
| Zdroj: | Psychophysiology |
| ISSN: | 1540-5958 0048-5772 |
| Popis: | Skin conductance responses (SCR) are increasingly analyzed with model‐based approaches that assume a linear and time‐invariant (LTI) mapping from sudomotor nerve (SN) activity to observed SCR. These LTI assumptions have previously been validated indirectly, by quantifying how much variance in SCR elicited by sensory stimulation is explained under an LTI model. This approach, however, collapses sources of variability in the nervous and effector organ systems. Here, we directly focus on the SN/SCR mapping by harnessing two invasive methods. In an intraneural recording experiment, we simultaneously track SN activity and SCR. This allows assessing the SN/SCR relationship but possibly suffers from interfering activity of non‐SN sympathetic fibers. In an intraneural stimulation experiment under regional anesthesia, such influences are removed. In this stimulation experiment, about 95% of SCR variance is explained under LTI assumptions when stimulation frequency is below 0.6 Hz. At higher frequencies, nonlinearities occur. In the intraneural recording experiment, explained SCR variance is lower, possibly indicating interference from non‐SN fibers, but higher than in our previous indirect tests. We conclude that LTI systems may not only be a useful approximation but in fact a rather accurate description of biophysical reality in the SN/SCR system, under conditions of low baseline activity and sporadic external stimuli. Intraneural stimulation under regional anesthesia is the most sensitive method to address this question. |
| Databáze: | OpenAIRE |
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