The topography of brain damage at different stages of Parkinson's disease
| Autor: | Agosta F, Canu E, Stojković T, Pievani M, Tomić A, Sarro L, Dragašević N, Copetti M, Comi G, Kostić VS, Filippi M |
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| Přispěvatelé: | Agosta, F, Canu, E, Stojkovic, T, Pievani, M, Tomic, A, Sarro, L, Dragasevic, N, Copetti, M, Comi, G, Kostic, V., Filippi, Massimo, Stojković, T, Tomić, A, Dragašević, N, Kostić, V, Filippi, M |
| Rok vydání: | 2011 |
| Předmět: |
Aged
80 and over Male Brain Mapping Echo-Planar Imaging Brain Parkinson Disease Middle Aged Neuropsychological Tests Magnetic Resonance Imaging Neural Pathways Disease Progression Image Processing Computer-Assisted Educational Status Humans Brain Damage Chronic Female Age of Onset Atrophy Cognition Disorders Biomarkers Research Articles Aged |
| Zdroj: | Hum Brain Mapp |
| ISSN: | 1097-0193 |
| Popis: | This study investigated gray matter (GM) and white matter (WM) damage in 89 patients at different clinical stages of Parkinson's disease (PD) (17 early, 46 mild, 14 moderate, and 12 severe) to differentiate the trajectories of tissue injury in this condition. PD patients had a very little GM atrophy even at the more advanced stages of the disease. Microstructural damage to the WM occurs with increasing PD severity and involves the brainstem, thalamocortical pathways, olfactory tracts, as well as the major interhemispheric, limbic, and extramotor association tracts. The most marked WM damage was found in moderate vs. mild cases. WM damage correlated with the degree of global cognitive deficits. WM abnormalities beyond the nigrostriatal system accumulate with increasing PD severity. WM damage is likely to contribute to the more severe motor and nonmotor dysfunctions occurring in patients at the later stages. Hum Brain Mapp 34:2798–2807, 2013. © 2012 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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