[Transcription factors of the Ets family and morphogenesis of the vascular tree]
| Autor: | Mattot V, Vercamer C, Fabrice Soncin, Fafeur V, Vandenbunder B |
|---|---|
| Jazyk: | francouzština |
| Rok vydání: | 1999 |
| Předmět: |
Proto-Oncogene Proteins c-ets
Proto-Oncogene Protein c-fli-1 Retroviridae Proteins Oncogenic Gene Expression Regulation Developmental Transfection Immediate-Early Proteins DNA-Binding Proteins Proto-Oncogene Protein c-ets-1 Proto-Oncogene Proteins Morphogenesis Trans-Activators Animals Blood Vessels Humans Endothelium Vascular Early Growth Response Protein 1 Transcription Factors |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1295-0661 |
| Popis: | The expression of several members of the Ets family of transcription factors, Ets1, Erg and Fli, correlates with the occurrence of invasive processes such as angiogenesis during normal and pathological development. The description of the phenotype of cultured endothelial cells expressing the DNA binding domain of Ets1 suggests that members of the Ets family take part in the morphogenesis of the vascular tree. Although transient transfection experiments allowed the identification of putative targets genes for Ets1 during angiogenesis, deciphering the Ets1 regulation networks remains a major goal for the future. |
| Databáze: | OpenAIRE |
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