CD8+PD-L1+CXCR3+ polyfunctional T cell abundances are associated with survival in critical SARS-CoV-2-infected patients
| Autor: | Adam, Lucille, Rosenbaum, Pierre, Quentric, Paul, Parizot, Christophe, Bonduelle, Olivia, Guillou, Noëlline, Corneau, Aurélien, Dorgham, Karim, Miyara, Makoto, Luyt, Charles-Edouard, Guihot, Amélie, Gorochov, Guy, Combadière, Christophe, Combadière, Behazine |
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| Přispěvatelé: | Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité Mixte de Service Production et Analyse de données en Sciences de la vie et en Santé (PASS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Cytométrie Pitié-Salpêtrière (PASS-CYPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Azevedo, Chloe |
| Rok vydání: | 2021 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Immunity Cellular Receptors CXCR3 SARS-CoV-2 [SDV]Life Sciences [q-bio] CD8 Antigens Immunology Adaptive immunity T cells COVID-19 Epitopes T-Lymphocyte CD8-Positive T-Lymphocytes Lymphocyte Activation B7-H1 Antigen [SDV] Life Sciences [q-bio] Survival Rate Humans Female France Immunologic Memory Research Article |
| Zdroj: | JCI Insight JCI Insight, 2021, 6 (18), ⟨10.1172/jci.insight.151571⟩ |
| ISSN: | 2379-3708 |
| Popis: | International audience; The importance of the adaptive T cell response in the control and resolution of viral infection has been well established. However, the nature of T cell-mediated viral control mechanisms in life-threatening stages of COVID-19 has yet to be determined. The aim of the present study was to determine the function and phenotype of T cell populations associated with survival or death of patients with COVID-19 in intensive care as a result of phenotypic and functional profiling by mass cytometry. Increased frequencies of circulating, polyfunctional CD4+CXCR5+HLA-DR+ stem cell memory T cells (Tscms) and decreased proportions of granzyme B-expressing and perforin-expressing effector memory T cells were detected in recovered and deceased patients, respectively. The higher abundance of polyfunctional PD-L1+CXCR3+CD8+ effector T cells (Teffs), CXCR5+HLA-DR+ Tscms, and anti-nucleocapsid (anti-NC) cytokine-producing T cells permitted us to differentiate between recovered and deceased patients. The results from a principal component analysis show an imbalance in the T cell compartment that allowed for the separation of recovered and deceased patients. The paucity of circulating PD-L1+CXCR3+CD8+ Teffs and NC-specific CD8+ T cells accurately forecasts fatal disease outcome. This study provides insight into the nature of the T cell populations involved in the control of COVID-19 and therefore might impact T cell-based vaccine designs for this infectious disease. |
| Databáze: | OpenAIRE |
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