Venous versus arterial iron administration in haemodialysis. Influence on erythrocytes antioxidant parameters

Autor:	Cb, Dogaru, Cristina Capusa, Gaman L, Torac E, Lixandru D, Gilca M, Iosif L, Muscurel C, Stoian I, Mircescu G, Atanasiu V
Předmět:	Glutathione Peroxidase Erythrocytes Superoxide Dismutase Iron Catalase Antioxidants haemodialysis antioxidant parameters Injections Intra-Arterial Renal Dialysis Injections Intravenous Humans Case Presentations Sulfhydryl Compounds
Zdroj:	Europe PubMed Central Journal of Medicine and Life Scopus-Elsevier
Popis:	Introduction Intravenous iron administration in patients treated by haemodialysis for end stage renal disease can exacerbate oxidative stress by increasing the level of free redox active iron. A way to reduce the impact of iron on oxidative stress in haemodialysis patients may be the administration of iron through arterial extracorporeal circuit. Objective The aim of our study was to compare the influence of iron route of administration (venous versus arterial extracorporeal circuit infusion) on antioxidant parameters in red blood cells of haemodialysis patients in order to clarify if arterial iron administration can have positive impacts related to iron induced oxidative stress. Method Twenty stable patients on regular haemodialysis treatment were selected for the study. They were investigated in a cross-over design at 3 mid-week HD sessions, one week apart, without iron [HD basal] and with either IV infusion of 100mg iron sucrose over the first 20 minutes of HD session, via venous line [HDvenous], or the same solution infused on the arterial extracorporeal circulation [HDarterial]. Blood samples were drawn at 0 min, 40 min and 270 min. Erythrocytes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activity, non-protein thiol levels and total antioxidant capacity (TEAC) were analysed. Conclusion Haemodialysis significantly decreases the total antioxidant activity in erythrocytes. Iron supplementation, through venous or arterial extracorporeal route has no impact on the total antioxidant activity in red blood cells. Venous iron administration increases GPx activity in erythrocytes suggesting increased lipid peroxidation compared with arterial extracorporeal administration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b395c3bd56cf62b71e14214d0e3efd43 http://europepmc.org/abstract/med/26361515 Zobrazit plný text záznamu