Lipoteichoic acid and muramic acid modulate the expression of CD80/CD86 on THP-1 cells and CD28/CD152 on jurkat cells

Autor:	Galdiero, M., Pisciotta, M. G., Petrillo, G., Marinelli, A., Emilia Galdiero
Přispěvatelé:	Galdiero, Marilena, Pisciotta, Mg, Petrillo, G, Marinelli, Alessandra, Galdiero, E., Galdiero, M, Marinelli, A, Galdiero, Emilia
Předmět:	Lipopolysaccharides Membrane Glycoproteins Macrophages T-Lymphocytes Antigens Differentiation Teichoic Acids Jurkat Cells CD28 Antigens Gene Expression Regulation Antigens CD Muramic Acids B7-1 Antigen Humans CTLA-4 Antigen B7-2 Antigen
Zdroj:	Scopus-Elsevier
Popis:	The aim of this study is to evaluate the effect of lipoteichoic acid (LTA) and muramic acid (MA) on costimulatory molecules CD80/CD86 on THP-1 cells and CD28/CD152 on Jurkat cells. The interactions between these molecules strongly influence the immune response through the regulation of cytokine release which, on its own, is able to regulate the immunological response by a feedback mechanism. Our results show that LTA and MA regulate expression of CD86 on macrophages while the expression of CD80 remains unmodified. LTA and MA increase the expression of CD86 on THP-1 cells, a macrophage cell line. MA increased Jurkat T cells CD152 expression.
Databáze:	OpenAIRE
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