Management of cytomegalovirus infection after living donor liver transplantation
| Autor: | Yamanouchi, Kosho, Eguchi, Susumu, Takatsuki, Mitsuhisa, Kamohara, Yukio, Hidaka, Masaaki, Miyazaki, Kensuke, Inokuma, Takamitsu, Tajima, Yoshitsugu, Kanematsu, Takashi |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Time Factors Cytomegalovirus Antiviral Agents Risk Assessment ABO Blood-Group System Japan Risk Factors Ambulatory Care Living Donors Humans Valganciclovir Ganciclovir Aged Retrospective Studies Transplantation Incidence Middle Aged Liver Transplantation Hospitalization Logistic Models Treatment Outcome Liver Blood Group Incompatibility Cytomegalovirus Infections Multivariate Analysis Female Immunosuppressive Agents Foscarnet |
| Zdroj: | Hepato-gastroenterology. 59(113):231-234 |
| ISSN: | 0172-6390 |
| Popis: | Few studies on Cytomegalovirus (CMV) infection in adult-to-adult living donor liver transplantation (LDLT) have been reported. The aim of this study was to analyze the incidence, risk factors and management of CMV infection after LDLT.Retrospective analysis was performed with 72 consecutive adult cases.CMV antigenemia was demonstrated in 31 (43.1%) patients and 9 patients (12.5%) manifested fever. Twelve patients were treated with intravenous ganciclovir (GCV) injection. There was improvement in 10 patients; foscanet concomitant with CMV-IG was administered in one patient who had an adverse effect resulting in improvement and another one resulted in death from sepsis. Twelve patients were given oral valganciclovir (VGCV) and all showed improvement. ABO incompatible transplantation was associated with CMV infection after LDLT in both the univariate (p=0.005) and multivariate analyses (p=0.04). After discharge 12 out of 63 patients (19%) suffered from CMV infection and all of them were taking steroid.ABO incompatible transplantation was demonstrated as a risk factor for CMV infection during hospitalization. After discharge immunosuppressive status seemed to be more essential as a predictor for CMV infection. Routine examination to detect CMV antigenemia is needed especially in patients with potentially over-immunosuppressive conditions in out-patient clinics. |
| Databáze: | OpenAIRE |
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