Development of hepatocellular carcinoma in chronic hepatitis B patients with advanced fibrosis is independent of viral genotype

Autor: Kumar, R., Testoni, B., Fresquet, J., Lim, T.K., Hao, Y., Tan, H.H., Chow, W.C., Zoulim, F.
Přispěvatelé: Nuclear and Radioanalytical Chemistry, IGCAR, Kalpakkam-603102, Tamilnadu, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), CAS Key Laboratory of Geospace Environment, University of Science and Technology of China [Hefei] (USTC), Collaborative Innovation Center of Astronautical Science and Technology
Rok vydání: 2016
Předmět:
Zdroj: Journal of Medical Virology
Journal of Medical Virology, Wiley-Blackwell, 2017, 89 (5), pp.845-848. ⟨10.1002/jmv.24707⟩
ISSN: 1096-9071
0146-6615
DOI: 10.1002/jmv.24707⟩
Popis: International audience; Hepatitis B is leading cause of liver related morbidity in Asia with predominant genotypes B and C in East-Asia. Data on Serum, intrahepatic viral-markers, and long-term follow-up of prevalent genotypes (GT) B and C in patients with biopsy proven advanced fibrosis are sparse. To compare serum, intrahepatic viral-markers and development of hepatocellular carcinoma (HCC) in GT-B and C in patients with advanced fibrosis (Ishak \textgreater/= 4). Sixty-three treatment-naive patients identified with advanced fibrosis on liver-biopsy performed between 1998 and 2000 at Singapore General Hospital. FFPE tissue was available for 59 patients and serum for 42 patients. HBV-DNA was quantified in serum and liver while qHBsAg quantified in serum. Patients were followed-up till December 2015. The median age was 47 +/- 16 years, with 77.7% males. About 19 were GT-B, 43 patients were GT-C, and 1 had both GT-B and C. Mean follow-up was 13.5 years. The median serum HBV-DNA was 6.25 +/- 2.17 and 6.58 +/- 1.85 log IU/ml, serum HBsAg was 3.29 +/- 0.80 and 3.45 +/- 1.85 log IU/ml, and intrahepatic HBV-DNA was 0.52 +/- 3.73 copies/cell and 0.4 +/- 1.37 copies/cell in the GT-B and C, respectively (P \textgreater 0.1 in all). Complete cirrhosis (Ishak-6) was present in 47.6%, Ishak-5 fibrosis in 33.3%, and Ishak-4 fibrosis in 19% at recruitment. On follow-up HCC developed in 8/43 in GT-C and in 3/19 GT-B (P = 0.86). Advanced age and cirrhosis were significant factors for development of HCC. No difference in serum HBV-DNA, qHBsAg or intrahepatic HBV-DNA was seen in the two genotypes. HCC development seen over long-term follow-up was independent of genotypes in patients with advanced fibrosis. J. Med. Virol. (c) 2016 Wiley Periodicals, Inc
Databáze: OpenAIRE
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