| Autor: |
F C C, Klouwer, A, Meester-Delver, F M, Vaz, H R, Waterham, R C M, Hennekam, B T, Poll-The |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Clinical Genetics. 93(3):613-621 |
| ISSN: |
0009-9163 |
| DOI: |
10.1111/cge.13130 |
| Popis: |
The lack of a validated severity scoring system for individuals with Zellweger spectrum disorders (ZSD) hampers optimal patient care and reliable research. Here, we describe the development of such severity score and its validation in a large, well-characterized cohort of ZSD individuals. We developed a severity scoring system based on the 14 organs that typically can be affected in ZSD. A standardized and validated method was used to classify additional care needs in individuals with neurodevelopmental disabilities (Capacity Profile [CAP]). Thirty ZSD patients of varying ages were scored by the severity score and the CAP. The median score was 9 (range 6-19) with a median scoring age of 16.0 years (range 2-36 years). The ZSD severity score was significantly correlated with all 5 domains of the CAP, most significantly with the sensory domain (r = 0.8971, P = |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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