HIV and kidney: a dangerous liaison
| Autor: | Alessia Bertoldi, Crignis, Elisa, ANNA MISEROCCHI, ISABELLA BON, GIUSEPPINA MUSUMECI, SERENA LONGO, VANESSA D'URBANO, Gaetano La Manna, LEONARDO CALZA, Maria Carla Re |
|---|---|
| Přispěvatelé: | Biochemistry, Bertoldi, Alessia, De Crignis, Elisa, Miserocchi, Anna, Bon, Isabella, Musumeci, Giuseppina, Longo, Serena, D'Urbano, Vanessa, La Manna, Gaetano, Calza, Leonardo, Re, Maria Carla |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Scopus-Elsevier Europe PubMed Central Microbiologica, 40(1), 1-10. Luigi Ponzio e figlio Editori Alma Mater Studiorum Università di Bologna-IRIS |
| ISSN: | 1121-7138 |
| Popis: | Kidney disease represents an important health concern among HIV-infected individuals, with an estimated prevalence ranging between 2.4 and 17%. The widespread use of antiretroviral drugs has changed the epidemiology of kidney disease in the HIV positive population, drastically reducing the percentage of patients affected by HIV-associated nephropathy (HIVAN), a complication characterized by apoptosis and de-differentiation of renal epithelial cells and podocytes. However, impaired kidney function remains an important issue among HIV-infected patients because of their long-term exposure to antiretroviral drugs and the growing burden of traditional risk factors associated with chronic renal disease. Furthermore, since HIV infects renal epithelial cells, kidney is a potential reservoir site that needs to be considered in future eradication studies. This review summarizes the main risk factors associated with chronic kidney disease in HIV-infected patients and discusses the contribution of viral infection and antiretroviral therapy to the pathogenesis of renal damage, emphasizing the need to monitor kidney status during the follow-up of HIV-infected patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|