A genome wide association study of mathematical ability reveals an association at chromosome 3q29, a locus associated with autism and learning difficulties: A preliminary study
| Autor: | Baron-Cohen, S., Murphy, L., Chakrabarti, B., Craig, I., Mallya, U., Lakatosova, S., Rehnstrom, K., Peltonen, L., Wheelwright, S., Allison, C., Fisher, S., Warrier, V. |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Neuroinformatics Adolescent Genotype Quantitative Trait Loci Intelligence Social Sciences lcsh:Medicine Polymorphism Single Nucleotide Gene Frequency Mental Health and Psychiatry Genome-Wide Association Studies Genetics Medicine and Health Sciences Humans Psychology Autistic Disorder lcsh:Science GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Genome Human Learning Disabilities lcsh:R Cognitive Psychology Chromosome Mapping Biology and Life Sciences Computational Biology Human Genetics Genomics Genome Analysis Human Intelligence Cognitive Science Female lcsh:Q Chromosomes Human Pair 3 Mathematics Genome-Wide Association Study Research Article Neuroscience |
| Zdroj: | PLoS One, 9 PLoS One, 9, 5 PLoS ONE, Vol 9, Iss 5, p e96374 (2014) PLoS ONE PLoS One |
| ISSN: | 1932-6203 |
| Popis: | Mathematical ability is heritable, but few studies have directly investigated its molecular genetic basis. Here we aimed to identify specific genetic contributions to variation in mathematical ability. We carried out a genome wide association scan using pooled DNA in two groups of U.K. samples, based on end of secondary/high school national academic exam achievement: high (n = 419) versus low (n = 183) mathematical ability while controlling for their verbal ability. Significant differences in allele frequencies between these groups were searched for in 906,600 SNPs using the Affymetrix GeneChip Human Mapping version 6.0 array. After meeting a threshold of p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|