Predictive and prognostic significance of neuron-specific enolase (NSE) in non-small cell lung cancer
| Autor: | Tiseo, M., Ardizzoni, A., Cafferata, M. A., Loprevite, M., Chiaramondia, M., Filiberti, R., Marroni, P., Francesco Grossi, Paganuzzi, M. |
|---|---|
| Přispěvatelé: | Tiseo M, Ardizzoni A, Cafferata MA, Loprevite M, Chiaramondia M, Filiberti R, Marroni P, Gross F, Paganuzzi M |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male endocrine system Predictive factors prognostic factors neuron-specific enolase non-small cell lung cancer Lung Neoplasms Middle Aged Prognosis Immunohistochemistry nervous system Predictive Value of Tests Carcinoma Non-Small-Cell Lung Phosphopyruvate Hydratase Humans Female Prospective Studies Aged |
| Zdroj: | Scopus-Elsevier Europe PubMed Central |
| Popis: | Background: The Predictive and prognostic role of neuron-specific enolase (NSE) in non-small cell lung cancer (NSCLC) is still under debate. Patients and Methods: To study these aspects, serum NSE was prospectively measured at baseline of first-line chemotherapy treatment and tested for correlation with clinical outcome in 129 advanced NSCLC patients. Results: An objective response was achieved in 2 7 out of 65 (41.5%) patients with NSE = 8.6 ng/ml (p = 0.05). Logistic analysis confirmed the positive association between objective response and NSE values >= 8.6 ng/ml (odds ratio=1.69; 95% confidence interval: 1.09-2.63; p=0.02). Overall median survival was 10.8 months. A statistically significant prognostic effect on survival was found for performance status, stage and response to treatment, but not for baseline NSE value. Conclusion: Based on these data, baseline circulating tumor NSE levels appear to have a weak predictive role, but not a prognostic significance in patients with advanced NSCLC submitted to standard chemotherapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|