Recipient clinical risk factors predominate in possible transfusion-related acute lung injury
| Autor: | Toy, PTCY, Bacchetti, P, Grimes, BA, Gajić, O, Murphy, EL, Winters, JL, Gropper, MA, Hubmayr, RD, Matthay, MA, Wilson, GA, Koenigsberg, M, Lee, DC, Hirschler, NV, Lowell, CA, Schuller, RM, Gandhi, MJ, Norris, PJ, Mair, DC, Sanchez Rosen, R, Looney, MR |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Adolescent Acute Lung Injury Clinical Trials and Supportive Activities Clinical Sciences Immunology and over Cardiorespiratory Medicine and Haematology Article Young Adult Rare Diseases Risk Factors Clinical Research 80 and over Humans Prospective Studies Child Preschool Lung Acute Respiratory Distress Syndrome Aged Infant Transfusion Reaction Middle Aged Good Health and Well Being Cardiovascular System & Hematology Case-Control Studies Multivariate Analysis Female |
| Zdroj: | Transfusion, vol 55, iss 5 Toy, P; Bacchetti, P; Grimes, B; Gajic, O; Murphy, EL; Winters, JL; et al.(2015). Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion, 55(5), 947-952. doi: 10.1111/trf.12954. UCSF: Retrieved from: http://www.escholarship.org/uc/item/99f4m6x2 Toy, PTCY; Bacchetti, P; Grimes, BA; Gajić, O; Murphy, EL; Winters, JL; et al.(2015). Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion. doi: 10.1111/trf.12954. UCSF: Retrieved from: http://www.escholarship.org/uc/item/65s4t40j |
| DOI: | 10.1111/trf.12954. |
| Popis: | © 2014 AABB. Background: Possible transfusion-related acute lung injury (pTRALI) cases by definition have a clear temporal relationship to an alternative recipient risk factor for acute respiratory distress syndrome (ARDS). We questioned whether transfusion factors are important for the development of pTRALI. Study Design and Methods: In this nested case-control study, we prospectively identified 145 consecutive patients with pTRALI and randomly selected 163 transfused controls over a 4-year period at the University of California at San Francisco and the Mayo Clinic (Rochester, Minnesota). Results: For pTRALI, we found evidence against transfusion being important: receipt of plasma from female donors (odds ratio [OR], 0.82; 95% confidence interval [CI], 0.29-2.3; p = 0.70), total number of units transfused (OR, 0.99; 95% CI, 0.89-1.10; p = 0.86), and number of red blood cell and whole blood units transfused (OR, 0.78; 95% CI, 0.59-1.03; p = 0.079). In contrast, we found that risk for pTRALI was associated with additional recipient factors: chronic alcohol abuse (OR, 12.5; 95% CI, 2.8-55; p < 0.001), current smoker (OR, 4.2; 95% CI, 1.67-10.8; p = 0.0024), shock before transfusion (OR, 4.6; 95% CI, 2.0-10.7; p < 0.001), and positive fluid balance before transfusion (OR, 1.32/L; 95% CI, 1.20-1.44; p < 0.001). Conclusion: Recipient risk factors for ARDS rather than transfusion risk factors predominate in pTRALI. |
| Databáze: | OpenAIRE |
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