| Autor: |
Cole S, Bailey, Luke T, Wooster, Mary, Buswell, Sarvagna, Patel, Paul P, Pappagianopoulos, Kristian, Bakken, Casey, White, Melissa, Tanguay, Jasmine B, Blodgett, Aaron L, Baggish, Rajeev, Malhotra, Gregory D, Lewis |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Popis: |
OBJECTIVES: To characterize the functional and prognostic significance of oxygen uptake (VO(2)) kinetics following peak exercise in individuals with heart failure (HF). BACKGROUND: It is unknown to what extent patterns of VO(2) recovery following exercise reflect circulatory response during exercise in HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF). METHODS: We investigated patients (30 HFpEF, 20 HFrEF, and 22 controls) who underwent cardiopulmonary exercise testing (CPET) with invasive hemodynamic monitoring and a second distinct HF cohort (n=106) who underwent non-invasive CPET with assessment of long-term outcomes. Fick cardiac output (CO) and cardiac filling pressures were measured at rest and throughout exercise in the initial cohort. A novel metric, VO(2) recovery delay (VO(2)RD), defined as time until post-exercise VO(2) falls permanently below peak VO(2), was measured to characterize VO(2) recovery kinetics. RESULTS: VO(2)RD in patients with HFpEF (median (IQR), 25 (9,39) seconds) and HFrEF (28 (2,52) seconds) was in excess of controls (5 (0,7) seconds, p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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