Approaches to Assess Vitamin A Status in Settings of Inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) Project
| Autor: | Leila M. Larson, Junjie Guo, Anne M. Williams, Melissa F. Young, Sanober Ismaily, O Yaw Addo, David Thurnham, Sherry A. Tanumihardjo, Parminder S. Suchdev, Christine A. Northrop-Clewes |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Adolescent Nutritional Status lcsh:TX341-641 Global Health Article Young Adult retinol binding protein Pregnancy parasitic diseases Humans cardiovascular diseases Vitamin A Child Inflammation Vitamin A Deficiency Infant Anemia Middle Aged infection Child Preschool Female biological phenomena cell phenomena and immunity lcsh:Nutrition. Foods and food supply Biomarkers retinol |
| Zdroj: | Nutrients Volume 10 Issue 8 Nutrients, Vol 10, Iss 8, p 1100 (2018) |
| ISSN: | 2072-6643 |
| Popis: | The accurate estimation of vitamin A deficiency (VAD) is critical to informing programmatic and policy decisions that could have important public health implications. However, serum retinol and retinol binding protein (RBP) concentrations, two biomarkers often used to estimate VAD, are temporarily altered during the acute phase response, potentially overestimating the prevalence of VAD in populations with high levels of inflammation. In 22 nationally-representative surveys, we examined (1) the association between C-reactive protein (CRP) or &alpha 1-acid glycoprotein (AGP) and retinol or RBP, and (2) how different adjustment approaches for correcting for inflammation compare with one another. In preschool age children (PSC) and school age children (SAC), the association between inflammation and retinol and RBP was largely statistically significant using the regression approach, adjustments for inflammation decreased the estimated prevalence of VAD compared to unadjusted VAD (range: &minus 22.1 to &minus 6.0 percentage points). In non-pregnant women of reproductive age (WRA), the association between inflammation and vitamin A biomarkers was inconsistent, precluding adjustments for inflammation. The burden of VAD can be overestimated if inflammation is not accounted for, and the regression approach provides a method for adjusting retinol and RBP for inflammation across the full range of concentrations in PSC and SAC. |
| Databáze: | OpenAIRE |
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