Pro-calcitonin and inflammation in chronic hemodialysis
| Autor: | Hernán Trimarchi, Mariana Dicugno, Alexis Muryan, Fernando Lombi, Leticia Iturbe, María S. Raña, Pablo Young, Karin Nau, Romina Iriarte, Vanesa Pomeranz, Mariano Forrester, Alejandra Karl, Mirta Alonso |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Adult Calcitonin Male Vasculitis Time Factors Calcitonin Gene-Related Peptide lcsh:Medicine Nutritional Status lcsh:Infectious and parasitic diseases Procalcitonina Sex Factors Predictive Value of Tests Reference Values Renal Dialysis parasitic diseases Humans lcsh:RC109-216 Protein Precursors Aged Aged 80 and over Hemodiálisis Inflamación lcsh:R Age Factors Bacterial Infections Middle Aged C-Reactive Protein Cross-Sectional Studies Case-Control Studies Kidney Failure Chronic Female Proteína C reactiva lcsh:RC581-607 hormones hormone substitutes and hormone antagonists Biomarkers |
| Zdroj: | Medicina (Buenos Aires), Vol 73, Iss 5, Pp 411-416 (2013) |
| ISSN: | 0025-7680 |
| Popis: | Procalcitonin (PCT) has emerged as a marker of infection, a frequent complication in hemodialysis (HD). We analyzed PCT levels in chronic non-acutely infected HD subjects, assessed its correlation with inflammatory and nutritional markers and propose a PCT reference value for non-infected HD patients.In an observational cross-sectional study, 48 chronic HD patients and 36 controls were analyzed. Variables: age, gender, time on HD; diabetes; vascular access, PCT, C-reactive protein (CRP), albumin, malnutrition inflammatory score (MIS), hematocrit, leukocyte count, and body mass index (BMI). Subsequently, control (G1, n = 36, 43%) vs. non-infected patients (G2, n = 48, 57%) groups were compared. In control subjects (G1), age: 54.3 ± 13.7 years, range (r): 30-81; males: 19 (53%); median PCT 0.034 ng/ml (r: 0.02-0.08); median CRP 0.80 mg/dl (r: 0.36-3.9); p95 PCT level: 0.063 ng/ml. In G2, age: 60.2 ± 15.2 years; males 32 (67%), time on HD: 27.0 ± 24.4; diabetics: 19 (32%); median PCT: 0.26 ng/ml (r: 0.09-0.82); CRP: 1.1 mg/dl (r: 0.5-6.2); p95 PCT level: 0.8 ng/ml. In control subjects, PCT and CRP were significantly lower than in G2: PCT: 0.034 vs. 0.26 ng/ml, p = 0.0001; CRP: 0.8 vs. 1.1 mg/dl, p = 0.0004. PCT-CRP correlation in G2: ρ = 0.287, p = 0.048. PCT and CRP concentrations are elevated in chronic non-acutely infected HD subjects, independently of infection, diabetes and vascular access. A p95 PCT level of 0.8 ng/ml may be considered as the upper normal reference value in non-acutely infected HD subjects. The PCT cut-off level in HD is yet to be determined in HD. |
| Databáze: | OpenAIRE |
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