Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany
| Autor: | Streeck, Hendrik, Schulte, Bianca, Kümmerer, Beate M., Richter, Enrico, Höller, Tobias, Fuhrmann, Christine, Bartok, Eva, Dolscheid-Pommerich, Ramona, Berger, Moritz, Wessendorf, Lukas, Eschbach-Bludau, Monika, Kellings, Angelika, Schwaiger, Astrid, Coenen, Martin, Hoffmann, Per, Stoffel-Wagner, Birgit, Nöthen, Markus M., Eis-Hübinger, Anna M., Exner, Martin, Schmithausen, Ricarda Maria, Schmid, Matthias, Hartmann, Gunther |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Adolescent Epidemiology Science General Physics and Astronomy Comorbidity Polymerase Chain Reaction General Biochemistry Genetics and Molecular Biology Article Young Adult COVID-19 Testing Germany Prevalence Humans Mortality lcsh:Science Child Aged Aged 80 and over Family Characteristics SARS-CoV-2 COVID-19 General Chemistry Middle Aged Viral infection Immunoglobulin G lcsh:Q Female |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | A SARS-CoV2 super-spreading event occurred during carnival in a small town in Germany. Due to the rapidly imposed lockdown and its relatively closed community, this town was seen as an ideal model to investigate the infection fatality rate (IFR). Here, a 7-day seroepidemiological observational study was performed to collect information and biomaterials from a random, household-based study population. The number of infections was determined by IgG analyses and PCR testing. We found that of the 919 individuals with evaluable infection status, 15.5% (95% CI:[12.3%; 19.0%]) were infected. This is a fivefold higher rate than the reported cases for this community (3.1%). 22.2% of all infected individuals were asymptomatic. The estimated IFR was 0.36% (95% CI:[0.29%; 0.45%]) for the community and 0.35% [0.28%; 0.45%] when age-standardized to the population of the community. Participation in carnival increased both infection rate (21.3% versus 9.5%, p Here the authors present a SARS-CoV2 seroepidemiological observational study from a random, household-based study population in a small town in Germany, showing the effect of a super-spreading event on infection rate, severity, and potentially infection fatality rate. |
| Databáze: | OpenAIRE |
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