Association of a NOS3 gene polymorphism with Behçet’s disease but not with Vogt-Koyanagi-Harada syndrome in Han Chinese
| Autor: | Zhou, Yan, Yu, Hongsong, Hou, Shengping, Fang, Jing, Qin, Jieying, Yuan, Gangxiang, Kijlstra, Aize, Yang, Peizeng |
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| Přispěvatelé: | RS: MHeNs - R3 - Neuroscience, MUMC+: MA Oogheelkunde (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male China Genotyping Techniques Nitric Oxide Synthase Type III Behcet Syndrome Nitric Oxide Synthase Type II Polymerase Chain Reaction Polymorphism Single Nucleotide eye diseases body regions Young Adult Asian People Gene Frequency Case-Control Studies cardiovascular system Humans Female cardiovascular diseases Uveomeningoencephalitic Syndrome Polymorphism Restriction Fragment Length Research Article |
| Zdroj: | Molecular Vision Molecular Vision, 22, 311-318. Molecular Vision |
| ISSN: | 1090-0535 |
| Popis: | Purpose: Previous studies have identified that nitric oxide synthase (NOS) genes are associated with several immune-mediated diseases. This study aimed to investigate whether NOS2 and NOS3 gene polymorphisms are associated with Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population.Methods: An association analysis of NOS2/rs4795067, NOS3/rs1799983 and NOS3/rs1800779 was performed in 733 patients with BD, 800 patients with VKH syndrome, and 1,359 controls using PCR restriction fragment length polymorphism (PCR-RFLP) assay. Statistical analysis was performed with the chi-square test followed by the Bonferroni correction.Results: The result showed a decreased frequency of the NOS3/rs1799983 GG genotype and an increased frequency of NOS3/rs1799983 GT genotype in the patients with BD (Bonferroni correction test [Pc]=0.02, odds ratio [OR]=0.74; Pc=2.1x10(-3), OR=1.57, respectively). No significant association was found between rs1799983 and VKH syndrome. NOS2/rs4795067 and NOS3/rs1800779 were not associated with either BD or VKH syndrome.Conclusions: Our findings suggest that a NOS3/rs1799983polymorphism is associated with susceptibility to BD in Han Chinese. |
| Databáze: | OpenAIRE |
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