RET/PTC ONCOGENE ACTIVATION IS AN EARLY EVENT IN THYROID CARCINOGENESIS
| Autor: | Viglietto, G., Chiappetta, G., Martinez-Tello, F. J., Fukunaga, F. H., Giovanni Tallini, Rigopoulou, D., Visconti, R., Mastro, A., Santoro, M., Fusco, A. |
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| Přispěvatelé: | G., Viglietto, G., Chiappetta, F. J., Martineztello, F. H., Fukunaga, G., Tallini, D., Rigopoulou, R., Visconti, A., Mastro, Santoro, Massimo, Fusco, Alfredo |
| Předmět: |
endocrine system
endocrine system diseases Base Sequence Molecular Sequence Data Proto-Oncogene Proteins c-ret Receptor Protein-Tyrosine Kinases Polymerase Chain Reaction Carcinoma Papillary Gene Expression Regulation Neoplastic Proto-Oncogene Proteins Proto-Oncogenes Drosophila Proteins Humans Thyroid Neoplasms |
| Zdroj: | Publons Scopus-Elsevier Oncogene (Basingstoke) 11 (1995): 1207–1210. info:cnr-pdr/source/autori:Viglietto G; Chiappetta G; Martinez-Tello FJ; Fukunaga FH; Tallini G; Rigopoulou D; Visconti R; Mastro A; Santoro M; Fusco A/titolo:RET%2FPTC oncogene activation is an early event in thyroid carcinogenesis/doi:/rivista:Oncogene (Basingstoke)/anno:1995/pagina_da:1207/pagina_a:1210/intervallo_pagine:1207–1210/volume:11 |
| Popis: | RET/PTC oncogene activation occurs in about 20% of human thyroid papillary carcinomas. However, it is not known yet whether it is an early or late event in the process of thyroid carcinogenesis. Here we demonstrate, by using a combined immunohistochemical and reverse transcriptase-polymerase chain reaction based approach, that RET/PTC activation is present in 11 out of 26 occult thyroid papillary carcinomas analysed. Therefore, we conclude that it represents an early event in the process of thyroid cell transformation. |
| Databáze: | OpenAIRE |
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