Evolution of Estrogen Receptor Status from Primary Tumors to Metastasis and Serially Collected Circulating Tumor Cells
Autor: | Carina Forsare, Pär-Ola Bendahl, Eric Moberg, Charlotte Levin Tykjær Jørgensen, Sara Jansson, Anna-Maria Larsson, Kristina Aaltonen, Lisa Rydén |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Adult
Breast Neoplasms circulating tumor cells Article lcsh:Chemistry breast cancer Neoplasms Biomarkers Tumor Humans metastasis Neoplasm Metastasis lcsh:QH301-705.5 Aged Neoplasm Staging Aged 80 and over estrogen receptor: tumor progression Middle Aged Neoplastic Cells Circulating Prognosis Survival Analysis lcsh:Biology (General) lcsh:QD1-999 Receptors Estrogen Disease Progression Female Follow-Up Studies |
Zdroj: | International Journal of Molecular Sciences Volume 21 Issue 8 International Journal of Molecular Sciences, Vol 21, Iss 2885, p 2885 (2020) |
ISSN: | 1422-0067 |
DOI: | 10.3390/ijms21082885 |
Popis: | Background: The estrogen receptor (ER) can change expression between primary tumor (PT) and distant metastasis (DM) in breast cancer. A tissue biopsy reflects a momentary state at one location, whereas circulating tumor cells (CTCs) reflect real-time tumor progression. We evaluated ER-status during tumor progression from PT to DM and CTCs, and related the ER-status of CTCs to prognosis. Methods: In a study of metastatic breast cancer, blood was collected at different timepoints. After CellSearch® enrichment, CTCs were captured on DropMount slides and evaluated for ER expression at baseline (BL) and after 1 and 3 months of therapy. Comparison of the ER-status of PT, DM, and CTCs at different timepoints was performed using the McNemar test. The primary endpoint was progression-free survival (PFS). Results: Evidence of a shift from ER positivity to negativity between PT and DM was demonstrated (p = 0.019). We found strong evidence of similar shifts from PT to CTCs at different timepoints (p < 0.0001). ER-positive CTCs at 1 and 3 months were related to better prognosis. Conclusions: A shift in ER-status from PT to DM/CTCs was demonstrated. ER-positive CTCs during systemic therapy might reflect the retention of a favorable phenotype that still responds to therapy. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |