Cell therapy of pseudarthrosis
| Autor: | Bastos Filho, R, Lermontov, S, Borojevic, R, Schott, PC, Gameiro, VS, Granjeiro, JM |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
musculoskeletal diseases
NONUNIONS Bone marrow cells Science & Technology SYSTEM SEPAX Tibia 1103 Clinical Sciences Fracture healing Stem cells musculoskeletal system FRACTURE Pseudarthrosis Orthopedics CREST BONE-GRAFT Original Article Femur MORPHOGENETIC PROTEINS Life Sciences & Biomedicine 1199 Other Medical and Health Sciences |
| Zdroj: | Acta Ortopedica Brasileira |
| ISSN: | 1809-4406 1413-7852 |
| Popis: | Objective To assess the safety and efficiency of cell therapy for pseudarthrosis. Implant of the bone marrow aspirate was compared to mononuclear cells purified extemporaneously using the Sepax® equipment. Methods Six patients with nonunion of the tibia or femur were treated. Four received a percutaneous infusion of autologous bone marrow aspirated from the iliac crest, and two received autologous bone marrow mononuclear cells separated from the aspirate with the Sepax®. The primary fixation method was unchanged, and the nonunion focus was not exposed. Physical examination and radiographies were performed 2, 4 and 6 months after the treatment by the same physician. After consolidation of the fracture the satisfaction of the patients was estimated using the adapted QALY scale. Results No complications occurred as a result of the referred procedures. Bone consolidation was obtained in all cases within 3 to 24 weeks. The degree of patient satisfaction before and after bone consolidation was assessed, with the average value increasing from two to nine (p=0.0156). Conclusion We conclude that the proposed method is effective and safe for the treatment of nonunion of long bones regardless of the stabilization method used. Level of Evidence II, Prospective Comparative Study |
| Databáze: | OpenAIRE |
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