[Genomic profiling by comparative genomic hybridization: analysis of ten enucleated uveal melanoma cases]
| Autor: | Abi-Ayad, N., Couturier, J., Devouassoux-Shisheboran, Mojgan, Grange, J.-D., Kodjikian, Laurent, Calender, A. |
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| Přispěvatelé: | Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), equipe 4, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL) |
| Jazyk: | francouzština |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Uveal Neoplasms MESH: Melanoma [SDV.CAN]Life Sciences [q-bio]/Cancer MESH: Eye Enucleation Eye Enucleation MESH: Gene Expression Profiling MESH: Aged 80 and over Humans Melanoma Aged Retrospective Studies Aged 80 and over MESH: Aged Comparative Genomic Hybridization MESH: Middle Aged MESH: Humans Gene Expression Profiling MESH: Adult MESH: Retrospective Studies Middle Aged MESH: Male MESH: Comparative Genomic Hybridization Female MESH: Uveal Neoplasms MESH: Female |
| Zdroj: | Journal Français D'Ophtalmologie Journal Français D'Ophtalmologie, Elsevier Masson, 2011, 34 (1), pp.17-23. ⟨10.1016/j.jfo.2010.10.013⟩ |
| ISSN: | 0181-5512 |
| DOI: | 10.1016/j.jfo.2010.10.013⟩ |
| Popis: | International audience; AIM: To detect major chromosomal aberrations from enucleated uveal melanoma and relate them to hepatic metastasis and survival. PATIENTS AND METHODS: Ten uveal melanomas enucleated between 2005 and 2008 in the Lyon Croix-Rousse Hospital were retrospectively analyzed using a 19 000-clone comparative genomic hybridization microarray. RESULTS: The most frequent imbalances were the loss of chromosome 3 (8/10), gain of the 8q arm (7/10) or the entire chromosome 8 (2/10), and gain of the 6p arm (2/10). Most metastatic tumors (6/7) and all cases of death (5/5) concerned melanoma with monosomy 3 and gain of the 8q arm. DISCUSSION AND CONCLUSION: Genome-wide array comparative genomic hybridization is a reliable tool for identifying uveal melanoma genomic imbalances. Gains of the 8q arm with monosomy 3 are frequent and are strongly associated with poor outcome. Gains of the 6p arm are rare and have a better prognosis. There is a mutually exclusive relationship between monosomy 3 and chromosome 6 abnormalities in our study. These results confirm previously published reports. |
| Databáze: | OpenAIRE |
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