Characterisation of a novel SCCmec VI element harbouring fusC in an emerging Staphylococcus aureus strain from the Arabian Gulf region

Autor: Senok, Abiola, Slickers, Peter, Hotzel, Helmut, Boswihi, Samar, Braun, Sascha D., Gawlik, Darius, Müller, Elke, Nabi, Anju, Nassar, Rania, Nitschke, Hedda, Reissig, Annett, Ruppelt-Lorz, Antje, Mafofo, Joseph, Somily, Ali M., Udo, Edet, Ehricht, Ralf, Monecke, Stefan
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus
Asia
Bioinformatics
Staphylococcus
Science
Saudi Arabia
Sequence Databases
United Arab Emirates
Research and Analysis Methods
Microbiology
Geographical locations
Database and Informatics Methods
Genetic Elements
Bacterial Proteins
Antibiotics
Microbial Control
Drug Resistance
Bacterial
Genetics
Humans
Pathology and laboratory medicine
Oligonucleotide Array Sequence Analysis
Medicine and health sciences
Pharmacology
Biology and life sciences
Bacteria
Antimicrobials
Organisms
Drugs
Genetic Variation
Medical microbiology
biochemical phenomena
metabolism
and nutrition
bacterial infections and mycoses
Microbial pathogens
Anti-Bacterial Agents
Biological Databases
Kuwait
Genes
Bacterial
Medicine
Bacterial pathogens
Antimicrobial Resistance
Pathogens
People and places
Sequence Analysis
Fusidic Acid
Research Article
Plasmids
Zdroj: PLoS ONE, Vol 14, Iss 11, p e0223985 (2019)
PLoS ONE
ISSN: 1932-6203
Popis: Fusidic acid is a steroid antibiotic known since the 1960s. It is frequently used in topical preparations, i.e., ointments, for the treatment of skin and soft tissue infections caused by Staphylococcus aureus. There is an increasing number of methicillin-resistant S. aureus (MRSA) strains that harbour plasmid-borne fusB/far1 or fusC that is localised on SCC elements. In this study we examined a series of related CC30-MRSA isolates from the Arabian Gulf countries that presented with SCCmec elements and fusC, including a variant that-to the best of our knowledge-has not yet formally been described. It consisted of a class B mec complex and ccrA/B-4 genes. The fusidic acid resistance gene fusC was present, but contrary to the previously sequenced element of HDE288, it was not accompanied by tirS. This element was identified in CC30 MRSA from Kuwait, Saudi Arabia and the United Arab Emirates that usually also harbour the Panton-Valentin leukocidin (PVL) genes. It was also identified in CC8 and ST834 isolates. In addition, further CC30 MRSA strains with other SCCmec VI elements harbouring fusC were found to circulate in the Arabian Gulf region. It can be assumed that MRSA strains with SCCmec elements that include fusC have a selective advantage in both hospital and community settings warranting a review of the use of topical antibiotics and indicating the necessity of reducing over-the-counter sale of antibiotics, including fusidic acid, without prescription.
Databáze: OpenAIRE
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