Modelling the Impact of Chronic Cigarette Smoke Exposure in Obese Mice: Metabolic, Pulmonary, Intestinal, and Cardiac Issues

Autor: Rémy, Gaëlle, Dubois-Deruy, Emilie, Alard, Jeanne, Kervoaze, Gwenola, Chwastyniak, Maggy, Baron, Morgane, Beury, Delphine, Siegwald, Léa, Caboche, Ségolène, Hot, David, Gosset, Philippe, Grangette, Corinne, Pinet, Florence, Wolowczuk, Isabelle, Pichavant, Muriel
Přispěvatelé: Pinet, Florence, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), This project was supported by Conseil Régional Nord Pas-de-Calais - Région Hauts-de-France funds (Grant n° 15000241, Adipofume project) and cofounded by the European Union under the European Regional Development Fund (ERDF) and by the Hauts de France Regional council (contract n°17003781), the MEL (contract n°2016_ESR_05), and the French State (contract n°2017-R3-CTRL-Phase 1) (financially) and the Institut Pasteur de Lille, Inserm and CNRS (institutionally)., We thank the Animal Resource Center (PLEHTA) and the BICeL flow cytometry core facility of the 'Institut Pasteur de Lille'. We also thank the 'Plateforme d’Imagerie du vivant' of the 'Faculté de Médecine de Lille' for performing the micro MRI and the help for analysis, especially Florent Auger and Nicolas Durieux. We thank Véronique Peucelle and Denise Boutillier (Institut Pasteur de Lille, CIIL Lille, France) for technical assistance. Finally, we want to thank all the « smokers » who actively participated to the CS exposure of the mice., Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nutrients, Vol 12, Iss 3, p 827 (2020)
Nutrients
Nutrients, 2020, 12 (3), pp.827. ⟨10.3390/nu12030827⟩
Nutrients, MDPI, 2020, 12 (3), pp.827. ⟨10.3390/nu12030827⟩
ISSN: 2072-6643
Popis: International audience; Unhealthy lifestyle choices, such as bad eating behaviors and cigarette smoking, have major detrimental impacts on health. However, the interrelations between obesity and smoking are still not fully understood. We thus developed an experimental model of high-fat diet-fed obese C57BL/6 male mice chronically exposed to cigarette smoke. Our study evaluated for the first time the resulting effects of the combined exposure to unhealthy diet and cigarette smoke on several metabolic, pulmonary, intestinal, and cardiac parameters. We showed that the chronic exposure to cigarette smoke modified the pattern of body fat distribution in favor of the visceral depots in obese mice, impaired the respiratory function, triggered pulmonary inflammation and emphysema, and was associated with gut microbiota dysbiosis, cardiac hypertrophy and myocardial fibrosis.
Databáze: OpenAIRE
Externí odkaz: