| Autor: |
Cresi, F., Locatelli, E., Elena Maggiora, Di Nicola, P., Cester, E., Sabatino, G., Martano, C., Giuliani, F., Bertino, E. |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Scopus-Elsevier |
| Popis: |
The state of sleep/wakefulness is well known to influence esophageal acid exposure and the number of acid refluxes whereas it is uncertain whether the same is true of the non-acid refluxes that predominate in the newborns. To investigate the relationship between sleep/wakefulness and refluxes 45 newborns with gastroesophageal reflux symptoms were studied with combined multichannel intraluminal impedance and pH monitoring. We found that sleep/wakefulness influenced acid and weakly acidic reflux frequency (awake 2.6+/-0.8; asleep 2.1+/-1.1; p=0.006). A negative correlation was found between sleepness periods and the mean reflux duration for both acid (R=0.55;p0.001) and weackly acidic (R=0.51;p0.001) refluxes. This finding may raise some concerns about the over-prescription of antacid drugs in newborns. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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