[Age dynamics of angiogenesis markers in transgenic HER-2/neu (FBV/N) mammary adenocarcinoma-prone mice]
| Autor: | Ap, Trashkov, Av, Panchenko, Rv, Korablev, Mn, Yurova, Pa, Egormin, Na, Chernenko, Ig, Popovich, Ml, Tyndyk, Margarita Artemenko, Na, Verlov, Ag, Vasiliev, Vn, Anisimov |
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| Předmět: |
Vascular Endothelial Growth Factor A
Aging Neovascularization Pathologic Receptor ErbB-2 Mammary Neoplasms Experimental Mammary Neoplasms Animal Mice Inbred Strains Mice Transgenic Adenocarcinoma Nitric Oxide Mice Tissue Plasminogen Activator Plasminogen Activator Inhibitor 1 Biomarkers Tumor Animals Female Insulin-Like Growth Factor I |
| Zdroj: | Europe PubMed Central |
| Popis: | Age-dependent angiogenesis intensity changes have been studied in transgenic HER-2/neu (FBV/N) mice characteristic of breast tumors' high incidence with hyperexpression of HER-2/neu. Concentration of vascular endothelial growth factor, insulin-dependent growth factor 1, nitrogen monoxide, tissue plasminogen activator and type 1 plasminogen activator inhibitor were assessed by means of immune-enzyme assay. The results testify to angiogenesis processes activation side by side with aging and growth of the tumors. Maximum manifestation of these disturbances (growth factors' blood concentrations increase and endotheliocytes' functional activity inhibition) has been revealed in 6-month-old mice during neoplasma maximum intensive and aggressive growth period. |
| Databáze: | OpenAIRE |
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