Association of Long-Term Diet Quality with Hippocampal Volume : Longitudinal Cohort Study

Autor: Akbaraly, T, Sexton, C, Zsoldos, E, Mahmood, A, Filippini, N, Kerleau, C, Michel Verdier, J, Virtanen, M, Gabelle, A, Ebmeier, K, Kivimaki, M
Přispěvatelé: Department of Epidemiology and Public Health, Imperial College London, Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Department of Psychiatry, University of Oxford [Oxford], Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Uppsala University, Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), University College of London [London] (UCL), Department of Public Health, Clinicum
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
HIGH-FAT DIET
Alternative Healthy Eating Index
Hippocampus
Article
Cohort Studies
Humans
Cognitive Dysfunction
Longitudinal Studies
Prospective Studies
BRAIN
Prospective study
Exercise
METAANALYSIS
ComputingMilieux_MISCELLANEOUS
Aged
Dietary indices
Nutrition and Dietetics
MORTALITY
Public Health
Global Health
Social Medicine and Epidemiology
Feeding Behavior
WHITEHALL II COHORT
Middle Aged
COGNITIVE IMPAIRMENT
DEPRESSION
Magnetic Resonance Imaging
Hippocampal volume
MEDITERRANEAN DIET
ALZHEIMERS-DISEASE
Näringslära
Folkhälsovetenskap
global hälsa
socialmedicin och epidemiologi
HEALTHY EATING INDEX
3121 General medicine
internal medicine and other clinical medicine
Older adults
Female
Diet
Healthy
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: The American Journal of Medicine
The American Journal of Medicine, Elsevier [Commercial Publisher] 2018, 131 (11), pp.1372-1381.e4. ⟨10.1016/j.amjmed.2018.07.001⟩
ISSN: 0002-9343
1555-7162
DOI: 10.1016/j.amjmed.2018.07.001⟩
Popis: BACKGROUND: Diet quality is associated with brain aging outcomes. However, few studies have explored in humans the brain structures potentially affected by long-term diet quality. We examined whether cumulative average of the Alternative Healthy Eating Index 2010 (AHEI-2010) score during adult life (an 11-year exposure period) is associated with hippocampal volume. METHODS: Analyses were based on data from 459 participants of the Whitehall II imaging sub-study (mean age [standard deviation] (SD) = 59.6 [5.3] years in 2002-2004, 19.2% women). Multimodal magnetic resonance imaging examination was performed at the end of follow-up (2015-2016). Structural images were acquired using a high-resolution 3-dimensional T1-weighted sequence and processed with Functional Magnetic Resonance Imaging of the Brain Software Library (FSL) tools. An automated model-based segmentation and registration tool was applied to extract hippocampal volumes. RESULTS: Higher AHEI-2010 cumulative average score (reflecting long-term healthy diet quality) was associated with a larger total hippocampal volume. For each 1 SD (SD = 8.7 points) increment in AHEI-2010 score, an increase of 92.5 mm(3) (standard error = 42.0 mm(3)) in total hippocampal volume was observed. This association was independent of sociodemographic factors, smoking habits, physical activity, cardiometabolic health factors, cognitive impairment, and depressive symptoms, and was more pronounced in the left hippocampus than in the right hippocampus. Of the AHEI-2010 components, no or light alcohol consumption was independently associated with larger hippocampal volume. CONCLUSIONS: Higher long-term AHEI-2010 scores were associated with larger hippocampal volume. Accounting for the importance of hippocampal structures in several neuropsychiatric diseases, our findings reaffirm the need to consider adherence to healthy dietary recommendation in multi-interventional programs to promote healthy brain aging. (C) 2018 The Authors. Published by Elsevier Inc.
Databáze: OpenAIRE
Externí odkaz: