Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain
| Autor: | Park, Ilwoo, Larson, Peder E. Z., Tropp, James L., Carvajal, Lucas, Reed, Galen, Bok, Robert, Robb, Fraser, Bringas, John, Kells, Adrian, Pivirotto, Philip, Bankiewicz, Krystof, Vigneron, Daniel B., Nelson, Sarah J. |
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| Rok vydání: | 2014 |
| Předmět: |
Carbon Isotopes
Magnetic Resonance Spectroscopy pyruvate Neurosciences Biomedical Engineering Brain Reproducibility of Results Equipment Design Hyperpolarized carbon-13 magnetic resonance spectroscopic imaging Magnetic Resonance Imaging Sensitivity and Specificity Article Equipment Failure Analysis dynamic nuclear polarization Macaca fascicularis Nuclear Medicine & Medical Imaging Pyruvic Acid Animals Humans Feasibility Studies Biomedical Imaging Female primate brain Lactic Acid |
| Zdroj: | Magnetic resonance in medicine, vol 71, iss 1 |
| Popis: | PurposeTo investigate hyperpolarized (13) C metabolic imaging methods in the primate brain that can be translated into future clinical trials for patients with brain cancer.Methods(13) C coils and pulse sequences designed for use in humans were tested in phantoms. Dynamic (13) C data were obtained from a healthy cynomolgus monkey brain using the optimized (13) C coils and pulse sequences. The metabolite kinetics were estimated from two-dimensional localized (13) C dynamic imaging data from the nonhuman primate brain.ResultsPyruvate and lactate signal were observed in both the brain and the surrounding tissues with the maximum signal-to-noise ratio of 218 and 29 for pyruvate and lactate, respectively. Apparent rate constants for the conversion of pyruvate to lactate and the ratio of lactate to pyruvate showed a difference between brain and surrounding tissues.ConclusionThe feasibility of using hyperpolarized [1-(13) C]-pyruvate for assessing in vivo metabolism in a healthy nonhuman primate brain was demonstrated using a hyperpolarized (13) C imaging experimental setup designed for studying patients with brain tumors. The kinetics of the metabolite conversion suggests that this approach may be useful in future studies of human neuropathology. |
| Databáze: | OpenAIRE |
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