High-sensitivity cardiac troponin I and the diagnosis of coronary artery disease in patients with suspected angina pectoris
| Autor: | Adamson, Philip D., Hunter, Amanda, Madsen, Debbie M., Shah, Anoop S.V., McAllister, David A., Pawade, Tania A., Williams, Michelle C., Berry, Colin, Boon, Nicholas A., Flather, Marcus, Forbes, John, McLean, Scott, Roditi, Giles, Timmis, Adam D., van Beek, Edwin J.R., Dweck, Marc R., Mickley, Hans, Mills, Nicholas L., Newby, David E. |
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| Přispěvatelé: | Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Edinburgh and Lothian’s Health Foundation Trust and the Heart Diseases Research Fund, British Heart Foundation |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Computed Tomography Angiography Denmark Clinical Decision-Making Coronary Artery Disease Coronary Angiography Severity of Illness Index Article Angina Pectoris angina cohort studies Predictive Value of Tests Risk Factors Multidetector Computed Tomography Journal Article Humans odds ratio Angina Stable humans Randomized Controlled Trials as Topic stable Diagnostic Tests Routine Troponin I Coronary Stenosis Reproducibility of Results Middle Aged Prognosis Scotland Female Biomarkers coronary artery disease |
| Zdroj: | Adamson, P D, Hunter, A, Madsen, D M, Shah, A S V, McAllister, D A, Pawade, T A, Williams, M C, Berry, C, Boon, N A, Flather, M, Forbes, J, McLean, S, Roditi, G, Timmis, A D, van Beek, E J R, Dweck, M R, Mickley, H, Mills, N L & Newby, D E 2018, ' High-Sensitivity Cardiac Troponin I and the Diagnosis of Coronary Artery Disease in Patients With Suspected Angina Pectoris ', Circulation: Cardiovascular Quality and Outcomes, vol. 11, no. 2, pp. e004227 . https://doi.org/10.1161/CIRCOUTCOMES.117.004227 |
| ISSN: | 1941-7713 |
| DOI: | 10.1161/CIRCOUTCOMES.117.004227 |
| Popis: | BACKGROUND: We determined whether high-sensitivity cardiac troponin I can improve the estimation of the pretest probability for obstructive coronary artery disease (CAD) in patients with suspected stable angina.METHODS AND RESULTS: In a prespecified substudy of the SCOT-HEART trial (Scottish Computed Tomography of the Heart), plasma cardiac troponin was measured using a high-sensitivity single-molecule counting assay in 943 adults with suspected stable angina who had undergone coronary computed tomographic angiography. Rates of obstructive CAD were compared with the pretest probability determined by the CAD Consortium risk model with and without cardiac troponin concentrations. External validation was undertaken in an independent study population from Denmark comprising 487 patients with suspected stable angina. Higher cardiac troponin concentrations were associated with obstructive CAD with a 5-fold increase across quintiles (9%-48%;PCONCLUSIONS: High-sensitivity cardiac troponin I concentration is an independent predictor of obstructive CAD in patients with suspected stable angina. Use of this test may improve the selection of patients for further investigation and treatment.CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01149590. |
| Databáze: | OpenAIRE |
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