| Autor: |
T W, de Bruin, R M, Slater, R, Defferrari, A, Geurts van Kessel, R F, Suijkerbuijk, G, Jansen, B, de Jong, J W, Oosterhuis |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Cancer research. 54(6) |
| ISSN: |
0008-5472 |
| Popis: |
We report the chromosomal characteristics of a recurrent pineal non-seminomatous germ cell tumor in a 16-year-old male patient. This non-seminomatous tumor had the following components: embryonal carcinoma, teratoma, yolk sac tumor, and trophoblastic giant cells. Chromosome analysis showed a near-triploid karyotype (64 chromosomes), including two copies of an isochromosome 12p. This latter finding could be confirmed using 12p-specific competitive in situ hybridization techniques applied to cultured cells (T2219-P6 cell line) derived from the tumor. The present findings are in keeping with the hypothesis that isochromosome 12p formation is associated with the development of malignant extragonadal germ cell tumors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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