Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus)
| Autor: | Rahman, Anisur, Lamberty, Yves, Schenker, Esther, Cella, Massimo, Languille, Solène, Bordet, Régis, Richardson, Jill, Pifferi, Fabien, Aujard, Fabienne |
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| Přispěvatelé: | Mécanismes Adaptatifs et Evolution (MECADEV), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), UCB Pharma S.A.[Braine-l'Alleud], Institut de Recherches SERVIER (IRS), Chiesi Farmaceutici, Université Lille Nord de France (COMUE), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), GlaxoSmithKline, Glaxo Smith Kline, This work was financially supported as part of the Pharma-Cog consortium by the European Community’s Seventh Framework Programme for the Innovative Medicine Initiative under Grant Agreement no. 115009., UCB Pharma [Brussels], Aujard, Fabienne |
| Rok vydání: | 2017 |
| Předmět: |
Male
Aging MESH: Aging/drug effects lcsh:Medicine Cognition Learning and Memory Piperidines Medicine and Health Sciences MESH: Animals Donepezil lcsh:Science Spatial Memory Animal Management Cognitive Impairment Mammals Cognitive Neurology MESH: Sleep Deprivation/physiopathology Neurodegenerative Diseases Agriculture Animal Models MESH: Alzheimer Disease/physiopathology Neurology Experimental Organism Systems Indans Vertebrates [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] MESH: Cheirogaleidae Cheirogaleidae MESH: Sleep Deprivation/complications Research Article MESH: Memory Disorders/etiology Primates Lemurs MESH: Sleep Deprivation/drug therapy Cognitive Neuroscience Prosimians Mouse Models Research and Analysis Methods Model Organisms MESH: Spatial Memory/drug effects Alzheimer Disease Memantine Memory Mental Health and Psychiatry Animals MESH: Alzheimer Disease/drug therapy [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] MESH: Alzheimer Disease/complications MESH: Donepezil Memory Disorders Animal Performance MESH: Memory Disorders/physiopathology lcsh:R MESH: Memantine/pharmacology Organisms Biology and Life Sciences Animal Cognition MESH: Male MESH: Memory Disorders/drug therapy Disease Models Animal MESH: Piperidines/pharmacology Amniotes Sleep Deprivation Cognitive Science lcsh:Q MESH: Indans/pharmacology Dementia MESH: Disease Models Animal Zoology Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2017, 12 (9), pp.e0184822. ⟨10.1371/journal.pone.0184822⟩ PLoS ONE, Vol 12, Iss 9, p e0184822 (2017) PLoS ONE, 2017, 12 (9), pp.e0184822. ⟨10.1371/journal.pone.0184822⟩ |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0184822⟩ |
| Popis: | International audience; The development of novel therapeutics to prevent cognitive decline of Alzheimer's disease (AD) is facing paramount difficulties since the translational efficacy of rodent models did not resulted in better clinical results. Currently approved treatments, including the acetylcholinesterase inhibitor donepezil (DON) and the N-methyl-D-aspartate antagonist memantine (MEM) provide marginal therapeutic benefits to AD patients. There is an urgent need to develop a predictive animal model that is phylogenetically proximal to humans to achieve better translation. The non-human primate grey mouse lemur (Microcebus murinus) is increasingly used in aging research, but there is no published results related to the impact of known pharmacological treatments on age-related cognitive impairment observed in this primate. In the present study we investigated the effects of DON and MEM on sleep-deprivation (SD)-induced memory impairment in young and aged male mouse lemurs. In particular, spatial memory impairment was evaluated using a circular platform task after 8 h of total SD. Acute single doses of DON or MEM (0.1 and 1mg/kg) or vehicle were administered intraperitoneally 3 h before the cognitive task during the SD procedure. Results indicated that both doses of DON were able to prevent the SD-induced deficits in retrieval of spatial memory as compared to vehicle-treated animals, both in young and aged animals Likewise, MEM show a similar profile at 1 mg/kg but not at 0.1mg/kg. Taken together, these results indicate that two widely used drugs for mitigating cognitive deficits in AD were partially effective in sleep deprived mouse lemurs, which further support the translational potential of this animal model. Our findings demonstrate the utility of this primate model for further testing cognitive enhancing drugs in development for AD or other neuropsychiatric conditions. |
| Databáze: | OpenAIRE |
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