Lipoprotein (a) concentrations, apolipoprotein (a) phenotypes, and peripheral arterial disease in three independent cohorts
| Autor: | Laschkolnig, A., Kollerits, B., Lamina, C., Meisinger, Christa, Rantner, B., Stadler, M., Peters, A., Koenig, W., Stockl, A., Dahnhardt, D., Boger, C. A., Kramer, B. K., Fraedrich, G., Strauch, K., Kronenberg, F. |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Ankle-brachial Index Apolipoprotein(a) Phenotypes Causality Lp(a) Concentrations Mendelian Randomization Peripheral Arterial Disease Apoprotein(a) Polymorphism Single Nucleotide Cohort Studies Risk Factors Mendelian randomization Humans Ankle Brachial Index Genetic Predisposition to Disease ddc:610 Aged Apolipoprotein(a) phenotypes Original Articles Lp(a) concentrations Intermittent Claudication Middle Aged Integrative Physiology and Pathophysiology Molecular Weight Phenotype Ankle-brachial index Linear Models Female Lipoprotein(a) |
| Zdroj: | Cardiovascular Research Cardiovasc. Res. 103, 28-36 (2014) |
| ISSN: | 1755-3245 |
| Popis: | AIMS: The relevance of lipoprotein(a) [Lp(a)] concentrations and low-molecular-weight (LMW) apo(a) phenotypes in peripheral arterial disease (PAD) has only been investigated by few studies. Therefore, we analysed this association in three independent cohorts and performed a Mendelian Randomization approach using instrumental variable regression. METHODS AND RESULTS: Lp(a) concentrations, apo(a) phenotypes, and one SNP in the LPA gene (rs10455872) were measured in the CAVASIC study, including 241 male patients with intermittent claudication and 246 age- and diabetes-matched controls as well as in the two population-based studies KORA F3 (n = 3184) and KORA F4 (n = 3080). In KORA F3/F4, 109/80 persons suffered from intermittent claudication, 200/144 from PAD, and 128/103 showed an ankle-brachial index (ABI) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|