| Autor: |
Jolanda van der Velden, Papp Z, Nm, Boontje, Zaremba R, Jw, Jong, Pm, Janssen, Hasenfuss G, Gj, Stienen |
| Rok vydání: |
2004 |
| Předmět: |
|
| Zdroj: |
Europe PubMed Central |
| ISSN: |
0065-2598 |
| Popis: |
The increased Ca(2+)-responsiveness in end-stage human heart failure cannot be attributed to contractile protein isoform changes, but rather is the complex resultant of changes in degree of phosphorylation of VLC-2 and TnI. Despite the decreased basal level of VLC-2 phosphorylation the response to VLC-2 dephosphorylation is enhanced in failing myocytes, which might result from differences in endogenous phosphorylation of thin and thick filament proteins between donor and failing hearts. Taken together decreased VLC-2 phosphorylation in end-stage human heart failure might represent a compensatory process leading to an improvement of myocardial contractility by opposing the detrimental effects of increased Ca(2+)-responsiveness of force and impaired Ca(2+)-handling on diastolic function. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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