Prenatal Iron Deficiency and Replete Iron Status Are Associated with Adverse Birth Outcomes, but Associations Differ in Ghana and Malawi
| Autor: | Oaks, Brietta M, Jorgensen, Josh M, Baldiviez, Lacey M, Adu-Afarwuah, Seth, Maleta, Ken, Okronipa, Harriet, Sadalaki, John, Lartey, Anna, Ashorn, Per, Ashorn, Ulla, Vosti, Stephen, Allen, Lindsay H, Dewey, Kathryn G |
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| Přispěvatelé: | Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Tampere University |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Malawi
Kansanterveystiede ympäristö ja työterveys - Public health care science environmental and occupational health Iron Ghana Food Sciences iron deficiency Animal Production Pregnancy parasitic diseases Humans low birth weight iron status Prenatal Nutritional Physiological Phenomena Growth Disorders low birth eight Nutrition and Dietetics Nutrition & Dietetics Anemia Iron-Deficiency Infant Newborn Pregnancy Outcome Infant preterm birth Anemia Iron-Deficiency Naisten- ja lastentaudit - Gynaecology and paediatrics Iron Deficiencies Infant Low Birth Weight Newborn anemia Nutrition Disorders Community and International Nutrition Infant Small for Gestational Age Small for Gestational Age Premature Birth Female newborn stunting |
| Zdroj: | The Journal of Nutrition The Journal of nutrition, vol 149, iss 3 |
| ISSN: | 1541-6100 0022-3166 |
| Popis: | BackgroundPrevious literature suggests a U-shaped relation between hemoglobin concentration and adverse birth outcomes. There is less evidence on associations between iron status and birth outcomes.ObjectiveOur objective was to determine the associations of maternal hemoglobin concentration and iron status with birth outcomes.MethodsWe conducted a secondary data analysis of data from 2 cohorts of pregnant women receiving iron-containing nutritional supplements (20-60 mg ferrous sulfate) in Ghana (n=1137) and Malawi (n=1243). Hemoglobin concentration and 2 markers of iron status [zinc protoporphyrin and soluble transferrin receptor (sTfR)] were measured at ≤20 weeks and 36 weeks of gestation. We used linear and Poisson regression models and birth outcomes included preterm birth (PTB), newborn stunting, low birth weight (LBW), and small-for-gestational-age.ResultsPrevalence of iron deficiency (sTfR >6.0 mg/L) at enrollment was 9% in Ghana and 20% in Malawi. In early pregnancy, iron deficiency was associated with PTB (9% compared with 17%, adjusted RR: 1.63; 95% CI: 1.14, 2.33) and stunting (15% compared with 23%, adjusted RR: 1.44; 95% CI: 1.09, 1.94) in Malawi but not Ghana, and was not associated with LBW in either country; replete iron status (sTfR |
| Databáze: | OpenAIRE |
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